E6-associated protein (E6AP)

URI: https://gptkb.org/entity/E6-associated_protein_(E6AP)
GPTKB entity
Statements (49)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alias gptkb:E6-AP
gptkb:UBE3A
gptkbp:associatedWith gptkb:cancer
gptkb:autism_spectrum_disorder
gptkb:Angelman_syndrome
gptkbp:biologicalProcess gptkb:synaptic_plasticity
regulation of transcription
ubiquitin-protein transferase activity
protein catabolic process
gptkbp:discoveredBy Huibregtse JM
gptkbp:discoveredIn 1993
gptkbp:domain gptkb:HECT_domain
E6 binding domain
gptkbp:encodedBy gptkb:UBE3A_gene
gptkbp:Entrez_Gene_ID 7337
gptkbp:function gptkb:E3_ubiquitin-protein_ligase
gptkbp:GO GO:0005634
GO:0004842
GO:0006511
gptkbp:HGNC_ID 12496
https://www.w3.org/2000/01/rdf-schema#label E6-associated protein (E6AP)
gptkbp:interactsWith gptkb:p53_protein
gptkb:HPV_E6_protein
gptkbp:involvedIn protein ubiquitination
gptkbp:length 875
gptkbp:locatedOnChromosome gptkb:15q11-q13
gptkbp:location gptkb:nucleus
gptkb:cytoplasm
gptkbp:molecularWeight 97 kDa
gptkbp:mutationAssociatedWith gptkb:Angelman_syndrome
loss of function causes Angelman syndrome
overexpression linked to autism
increased degradation of p53 in presence of HPV E6
gptkbp:OMIM 601623
gptkbp:organism gptkb:Homo_sapiens
gptkbp:orthologIn mouse Ube3a
rat Ube3a
gptkbp:pathway ubiquitin-mediated proteolysis
gptkbp:PDB 1C4Z
gptkbp:postTranslationalModification phosphorylation
ubiquitination
gptkbp:proteinFamily HECT E3 ligase family
gptkbp:species gptkb:human
gptkb:mouse
right
gptkbp:UniProtID gptkb:Q05086
gptkbp:bfsParent gptkb:E6AP-type_E3_ubiquitin_ligase_domain
gptkbp:bfsLayer 8