Statements (23)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alsoKnownAs |
retinoblastoma protein family
|
| gptkbp:binds |
gptkb:E2F_transcription_factors
|
| gptkbp:dephosphorylatedBy |
protein phosphatases
|
| gptkbp:discoveredIn |
1990s
|
| gptkbp:foundIn |
eukaryotes
|
| gptkbp:function |
regulation of cell cycle
tumor suppression |
| https://www.w3.org/2000/01/rdf-schema#label |
pRB family proteins
|
| gptkbp:includes |
gptkb:pRB
p107 p130 |
| gptkbp:inhibitedBy |
cell proliferation
|
| gptkbp:interactsWith |
gptkb:cyclin-dependent_kinases
|
| gptkbp:locale |
gptkb:nucleus
|
| gptkbp:member |
p107 (RBL1)
p130 (RBL2) pRB (RB1) |
| gptkbp:mutationAssociatedWith |
gptkb:cancer
|
| gptkbp:phosphorylates |
CDK/cyclin complexes
|
| gptkbp:regulates |
G1/S cell cycle transition
|
| gptkbp:bfsParent |
gptkb:E2F_family
|
| gptkbp:bfsLayer |
8
|