CYP3A4
E242412
CYP3A4 is a major human liver and intestinal enzyme of the cytochrome P450 family responsible for metabolizing a wide range of drugs and xenobiotics.
All labels observed (4)
| Label | Occurrences |
|---|---|
| CYP3A4 canonical | 45 |
| CYP3A | 2 |
| cytochrome P450 family 3 | 1 |
| cytochrome P450 family 3 subfamily A member 4 | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T2190668 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: CYP3A4 Context triple: [Xarelto, isMetabolizedBy, CYP3A4]
-
A.
BCRP
BCRP is the Central Reserve Bank of Peru, the country’s monetary authority responsible for maintaining monetary stability and managing its currency and international reserves.
-
B.
UGT
UGT is a major Spanish trade union confederation representing workers across multiple sectors and advocating for labor rights and social justice.
-
C.
CB1 receptor
The CB1 receptor is a G protein–coupled cannabinoid receptor in the brain and nervous system that mediates most of the psychoactive effects of cannabis.
-
D.
Corachol
Corachol is a subfamily of Uto-Aztecan languages that includes closely related indigenous languages spoken in western Mexico.
-
E.
CYP
CYP is the three-letter ISO 3166-1 alpha-3 country code assigned to Cyprus.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: CYP3A4 Target entity description: CYP3A4 is a major human liver and intestinal enzyme of the cytochrome P450 family responsible for metabolizing a wide range of drugs and xenobiotics.
-
A.
BCRP
BCRP is the Central Reserve Bank of Peru, the country’s monetary authority responsible for maintaining monetary stability and managing its currency and international reserves.
-
B.
UGT
UGT is a major Spanish trade union confederation representing workers across multiple sectors and advocating for labor rights and social justice.
-
C.
CB1 receptor
The CB1 receptor is a G protein–coupled cannabinoid receptor in the brain and nervous system that mediates most of the psychoactive effects of cannabis.
-
D.
Corachol
Corachol is a subfamily of Uto-Aztecan languages that includes closely related indigenous languages spoken in western Mexico.
-
E.
CYP
CYP is the three-letter ISO 3166-1 alpha-3 country code assigned to Cyprus.
- F. None of above. chosen
Statements (66)
| Predicate | Object |
|---|---|
| instanceOf |
cytochrome P450 enzyme
ⓘ
drug-metabolizing enzyme ⓘ enzyme ⓘ protein ⓘ |
| accountsFor | major fraction of total hepatic CYP content ⓘ |
| associatedWith |
drug–drug interactions
ⓘ
interindividual variability in drug response ⓘ |
| biologicalProcess |
drug metabolism
ⓘ
oxidation-reduction process ⓘ steroid metabolic process ⓘ xenobiotic metabolic process ⓘ |
| chromosomalBand | 7q22.1 ⓘ |
| cofactor | heme ⓘ |
| electronDonorProtein | cytochrome P450 reductase ⓘ |
| encodedByGene | CYP3A4 gene ⓘ |
| enzymeCommissionNumber | EC 1.14.14.1 ⓘ |
| family |
cytochrome P450 family 3
ⓘ
linked to:
CYP3A4
|
| fullName |
cytochrome P450 family 3 subfamily A member 4
ⓘ
linked to:
CYP3A4
|
| geneSymbol | CYP3A4 ⓘ |
| inducedBy |
St John’s wort
ⓘ
carbamazepine ⓘ phenytoin ⓘ rifampin ⓘ |
| inhibitedBy |
clarithromycin
ⓘ
grapefruit juice ⓘ itraconazole ⓘ ketoconazole ⓘ ritonavir ⓘ |
| isoformNumber | 4 ⓘ |
| locatedOnChromosome | chromosome 7 ⓘ |
| metabolizes |
atorvastatin
ⓘ
benzodiazepines ⓘ clarithromycin ⓘ cortisol ⓘ cyclosporine ⓘ erythromycin ⓘ lovastatin ⓘ midazolam ⓘ nifedipine ⓘ opioids ⓘ oral contraceptive steroids ⓘ protease inhibitors ⓘ simvastatin ⓘ tacrolimus ⓘ testosterone ⓘ verapamil ⓘ vitamin D analogs ⓘ |
| molecularFunction |
monooxygenase activity
ⓘ
oxidoreductase activity ⓘ |
| organism | Homo sapiens ⓘ |
| playsRoleIn |
first-pass metabolism
ⓘ
hepatic clearance of drugs ⓘ |
| polymorphic | true ⓘ |
| regulatedBy |
constitutive androstane receptor
ⓘ
pregnane X receptor ⓘ |
| requiresCofactor | NADPH ⓘ |
| subcellularLocation |
endoplasmic reticulum membrane
ⓘ
microsome ⓘ |
| subfamily | subfamily A ⓘ |
| tissueExpression |
brain
ⓘ
colon ⓘ kidney ⓘ liver ⓘ lung ⓘ small intestine ⓘ |
| uniprotId | P08684 ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: CYP3A4 Description of subject: CYP3A4 is a major human liver and intestinal enzyme of the cytochrome P450 family responsible for metabolizing a wide range of drugs and xenobiotics.
Referenced by (49)
Full triples — surface form annotated when it differs from this entity's canonical label.
subject linked to:
docetaxel
subject linked to:
H2 receptor antagonist cimetidine
subject linked to:
terfenadine
subject linked to:
cyclosporine A
subject linked to:
clobazam
linked to: CYP3A4
linked to: CYP3A4