Triple
T5981453
| Position | Surface form | Disambiguated ID | Type / Status |
|---|---|---|---|
| Subject | Donepezil |
E133125
|
entity |
| Predicate | metabolizedBy |
P37221
|
FINISHED |
| Object | CYP3A4 |
E242412
|
NE FINISHED |
How this triple was built (2 steps)
Every LLM step that produced this triple, in pipeline order — named-entity classification, the disambiguation choices (the exact options shown, with the pick highlighted), and the generated description. The batch + timestamp of each is in the Provenance table below.
NER
Named-entity recognition
gpt-5-mini
Instruction
Given a phrase, classify it is english named entity (e.g., persons, organizations, works of art) in Latin script, or not (e.g., literals, dates, URLs, verbose phrases). For disambiguation, the statement where the phrase occurs as object is also given. Please return a JSON object with `phrase` (string, the phrase being analyzed) and `is_ne` (boolean, indicating whether the phrase is a Named Entity).
Input
Phrase: CYP3A4 | Statement: [Donepezil, metabolizedBy, CYP3A4]
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: CYP3A4 Context triple: [Donepezil, metabolizedBy, CYP3A4]
-
A.
CYP3A4
chosen
CYP3A4 is a major human liver and intestinal enzyme of the cytochrome P450 family responsible for metabolizing a wide range of drugs and xenobiotics.
-
B.
CYP2J2
CYP2J2 is a human cytochrome P450 enzyme primarily expressed in the heart and other tissues, involved in the metabolism of various drugs and endogenous fatty acids.
-
C.
P-glycoprotein
P-glycoprotein is a membrane-bound efflux transporter protein that pumps various drugs and xenobiotics out of cells, influencing their absorption, distribution, and resistance profiles.
-
D.
BCRP
BCRP is the Central Reserve Bank of Peru, the country’s monetary authority responsible for maintaining monetary stability and managing its currency and international reserves.
-
E.
BCRP
BCRP (Breast Cancer Resistance Protein) is an ATP-binding cassette (ABC) efflux transporter involved in multidrug resistance and the transport of various drugs and xenobiotics across cellular membranes.
- F. None of above.
- G. Unsure - the case is ambiguous/there is not enough information to decide.
Provenance (3 batches)
The batch behind each pipeline step, in order, with when it ran. Timestamps are batch-level — stages were processed in waves, so the object chain (NER → NED1 → NEDg → NED2) reads in order, but predicate / elicitation batches can sit in a different wave.
| Step | Stage | Batch ID | Status | When |
|---|---|---|---|---|
| creating | Elicitation | batch_69c0086f45e8819098f73dd16d45ec9d |
completed | March 22, 2026, 3:19 p.m. |
| NER | Named-entity recognition | batch_69c0560bae148190ad4755defaaf471b |
completed | March 22, 2026, 8:50 p.m. |
| NED1 | Entity disambiguation (via context triple) | batch_69c0e42174a88190b8b40cbc7815911f |
completed | March 23, 2026, 6:56 a.m. |
Created at: March 22, 2026, 4:04 p.m.