pregnane X receptor
E850015
Pregnane X receptor is a nuclear hormone receptor that senses a wide range of xenobiotics and endogenous compounds to regulate genes involved in drug metabolism and detoxification.
All labels observed (2)
| Label | Occurrences |
|---|---|
| pregnane X receptor canonical | 3 |
| steroid and xenobiotic receptor | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T10214785 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: pregnane X receptor Context triple: [CYP3A4, regulatedBy, pregnane X receptor]
-
A.
CB2 receptor
The CB2 receptor is a cannabinoid receptor primarily expressed in immune and peripheral tissues, where it modulates inflammation and immune responses and serves as a key target of compounds like THC.
-
B.
CYP2J2
CYP2J2 is a human cytochrome P450 enzyme primarily expressed in the heart and other tissues, involved in the metabolism of various drugs and endogenous fatty acids.
-
C.
CB1 receptor
The CB1 receptor is a G protein–coupled cannabinoid receptor in the brain and nervous system that mediates most of the psychoactive effects of cannabis.
-
D.
thalidomide
Thalidomide is an immunomodulatory drug historically known for causing severe birth defects, now used under strict controls to treat conditions such as multiple myeloma and complications of leprosy.
-
E.
PZPR
PZPR was the ruling communist party that governed the Polish People's Republic from the late 1940s until the fall of communism in 1989.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: pregnane X receptor Target entity description: Pregnane X receptor is a nuclear hormone receptor that senses a wide range of xenobiotics and endogenous compounds to regulate genes involved in drug metabolism and detoxification.
-
A.
CB2 receptor
The CB2 receptor is a cannabinoid receptor primarily expressed in immune and peripheral tissues, where it modulates inflammation and immune responses and serves as a key target of compounds like THC.
-
B.
CYP2J2
CYP2J2 is a human cytochrome P450 enzyme primarily expressed in the heart and other tissues, involved in the metabolism of various drugs and endogenous fatty acids.
-
C.
CB1 receptor
The CB1 receptor is a G protein–coupled cannabinoid receptor in the brain and nervous system that mediates most of the psychoactive effects of cannabis.
-
D.
thalidomide
Thalidomide is an immunomodulatory drug historically known for causing severe birth defects, now used under strict controls to treat conditions such as multiple myeloma and complications of leprosy.
-
E.
PZPR
PZPR was the ruling communist party that governed the Polish People's Republic from the late 1940s until the fall of communism in 1989.
- F. None of above. chosen
Statements (61)
| Predicate | Object |
|---|---|
| instanceOf |
nuclear receptor
ⓘ
protein ⓘ transcription factor ⓘ xenobiotic sensor ⓘ |
| activatedBy |
bile acid derivatives
ⓘ
dexamethasone ⓘ hyperforin ⓘ phenobarbital ⓘ pregnenolone 16α-carbonitrile ⓘ rifampicin ⓘ |
| activatedState | ligand-bound heterodimer with RXRα ⓘ |
| alsoKnownAs |
NR1I2
ⓘ
linked to:
constitutive androstane receptor
PXR ⓘ SXR ⓘ steroid and xenobiotic receptor ⓘ
linked to:
pregnane X receptor
|
| associatedWith |
cholestatic liver disease
ⓘ
inflammatory bowel disease ⓘ metabolic disorders ⓘ |
| belongsToFamily | nuclear receptor subfamily 1 group I ⓘ |
| bindsDNAAt |
PXR response elements
ⓘ
xenobiotic response elements ⓘ |
| bindsLigand |
bile acids
ⓘ
endogenous steroids ⓘ herbal compounds ⓘ prescription drugs ⓘ xenobiotics ⓘ |
| biologicalProcess |
bile acid homeostasis
ⓘ
cholesterol metabolism ⓘ detoxification ⓘ lipid metabolism ⓘ regulation of drug clearance ⓘ xenobiotic metabolism ⓘ |
| chromosomalLocation | chromosome 3q13.33 ⓘ |
| discoveredIn | late 1990s ⓘ |
| encodedBy | NR1I2 gene ⓘ |
| expressedIn |
colon
ⓘ
intestine ⓘ kidney ⓘ liver ⓘ |
| formsHeterodimerWith |
RXRα
ⓘ
retinoid X receptor alpha ⓘ |
| hasDomain |
DNA-binding domain
ⓘ
ligand-binding domain ⓘ |
| hasOrtholog |
mouse Pxr
ⓘ
rat Pxr ⓘ |
| involvedIn |
drug–drug interactions
ⓘ
pharmacokinetic variability ⓘ |
| organism | Homo sapiens ⓘ |
| regulatesExpressionOf |
ABCB1
ⓘ
linked to:
P-glycoprotein
ABCC2 ⓘ CYP2B6 ⓘ CYP2C19 ⓘ CYP2C9 ⓘ CYP3A4 ⓘ MDR1 ⓘ
linked to:
P-glycoprotein
SULT2A1 ⓘ UGT1A1 ⓘ drug transporters ⓘ drug-metabolizing enzymes ⓘ |
| subcellularLocation |
cytoplasm
ⓘ
nucleus ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: pregnane X receptor Description of subject: Pregnane X receptor is a nuclear hormone receptor that senses a wide range of xenobiotics and endogenous compounds to regulate genes involved in drug metabolism and detoxification.
Referenced by (4)
Full triples — surface form annotated when it differs from this entity's canonical label.