Taxotere
E902896
Taxotere is a chemotherapy medication containing docetaxel, commonly used to treat various cancers such as breast, lung, prostate, and gastric cancers.
All labels observed (1)
| Label | Occurrences |
|---|---|
| Taxotere canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T11074695 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: Taxotere Context triple: [Docetaxel, tradeName, Taxotere]
-
A.
Herceptin
Herceptin is a targeted monoclonal antibody drug used primarily to treat HER2-positive breast cancer by blocking the HER2 receptor on cancer cells.
-
B.
Ibrance
Ibrance is a targeted oral cancer medication (palbociclib) used primarily to treat certain types of hormone receptor–positive, HER2-negative advanced or metastatic breast cancer.
-
C.
Alimta
Alimta is a chemotherapy drug (pemetrexed) primarily used to treat malignant pleural mesothelioma and non-small cell lung cancer.
-
D.
Seagen
Seagen is a biotechnology company specializing in the development of antibody-drug conjugate (ADC) therapies for cancer treatment.
-
E.
Zaltrap
Zaltrap is a cancer medication (brand name for aflibercept) used primarily in combination chemotherapy to treat metastatic colorectal cancer by inhibiting vascular endothelial growth factor (VEGF).
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: Taxotere Target entity description: Taxotere is a chemotherapy medication containing docetaxel, commonly used to treat various cancers such as breast, lung, prostate, and gastric cancers.
-
A.
Herceptin
Herceptin is a targeted monoclonal antibody drug used primarily to treat HER2-positive breast cancer by blocking the HER2 receptor on cancer cells.
-
B.
Ibrance
Ibrance is a targeted oral cancer medication (palbociclib) used primarily to treat certain types of hormone receptor–positive, HER2-negative advanced or metastatic breast cancer.
-
C.
Alimta
Alimta is a chemotherapy drug (pemetrexed) primarily used to treat malignant pleural mesothelioma and non-small cell lung cancer.
-
D.
Seagen
Seagen is a biotechnology company specializing in the development of antibody-drug conjugate (ADC) therapies for cancer treatment.
-
E.
Zaltrap
Zaltrap is a cancer medication (brand name for aflibercept) used primarily in combination chemotherapy to treat metastatic colorectal cancer by inhibiting vascular endothelial growth factor (VEGF).
- F. None of above. chosen
Statements (54)
| Predicate | Object |
|---|---|
| instanceOf |
brand name drug
ⓘ
chemotherapy medication ⓘ |
| contraindicatedIn |
patients with baseline neutrophil count below recommended threshold
ⓘ
severe hepatic impairment ⓘ |
| developedBy | Sanofi NERFINISHED ⓘ |
| dosageForm |
concentrate for solution for infusion
ⓘ
solution for infusion ⓘ |
| eliminationRoute | biliary excretion ⓘ |
| hasActiveIngredient | docetaxel NERFINISHED ⓘ |
| hasATCCode | L01CD02 ⓘ |
| hasDrugClass |
antineoplastic agent
ⓘ
mitotic inhibitor ⓘ taxane ⓘ |
| hasSeriousAdverseEffect |
cardiotoxicity
ⓘ
hepatotoxicity ⓘ interstitial lung disease ⓘ sepsis ⓘ severe neutropenia ⓘ |
| hasSideEffect |
alopecia
ⓘ
anemia ⓘ diarrhea ⓘ fatigue ⓘ febrile neutropenia ⓘ fluid retention ⓘ hypersensitivity reactions ⓘ mucositis ⓘ nausea ⓘ neutropenia ⓘ peripheral neuropathy ⓘ thrombocytopenia ⓘ vomiting ⓘ |
| indicationType | systemic cancer therapy ⓘ |
| mechanismOfAction |
inhibits mitosis in cancer cells
ⓘ
stabilizes microtubules and prevents depolymerization ⓘ |
| metabolism | hepatic ⓘ |
| metabolizedBy | CYP3A4 NERFINISHED ⓘ |
| oftenGivenWith |
cisplatin
ⓘ
cyclophosphamide NERFINISHED ⓘ doxorubicin ⓘ fluorouracil ⓘ prednisone ⓘ |
| pregnancyCategory | teratogenic risk (contraindicated in pregnancy) ⓘ |
| regulatoryStatus | prescription only ⓘ |
| requiresPremedicationWith | corticosteroids ⓘ |
| routeOfAdministration | intravenous ⓘ |
| targetsBiologicalProcess | microtubule dynamics ⓘ |
| usedForTreatmentOf |
breast cancer
ⓘ
gastric cancer ⓘ head and neck cancer ⓘ hormone-refractory metastatic prostate cancer ⓘ locally advanced breast cancer ⓘ metastatic breast cancer ⓘ non-small cell lung cancer ⓘ prostate cancer ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: Taxotere Description of subject: Taxotere is a chemotherapy medication containing docetaxel, commonly used to treat various cancers such as breast, lung, prostate, and gastric cancers.
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.