terfenadine
E850017
Terfenadine is a withdrawn second-generation antihistamine formerly used to treat allergy symptoms but discontinued due to its risk of causing serious cardiac arrhythmias.
All labels observed (1)
| Label | Occurrences |
|---|---|
| terfenadine canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T10214838 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: terfenadine Context triple: [CYP2J2, metabolizes, terfenadine]
-
A.
Fenodyree
Fenodyree is a mythical, goblin-like creature from Alan Garner’s fantasy novel "The Weirdstone of Brisingamen," known for aiding the protagonists with its otherworldly powers and knowledge of the hidden realms.
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B.
Benadryl
Benadryl is a widely used over-the-counter antihistamine medication commonly taken to relieve allergy symptoms such as sneezing, itching, and runny nose.
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C.
Allegra
Allegra is a widely used over-the-counter antihistamine medication for relieving allergy symptoms such as sneezing, runny nose, and itchy or watery eyes.
-
D.
Zyrtec
Zyrtec is a widely used over-the-counter antihistamine medication primarily taken to relieve allergy symptoms such as sneezing, runny nose, and itchy or watery eyes.
-
E.
Ripatransone
Ripatransone is a historic hilltop town in Italy’s Marche region, known for its medieval architecture, panoramic views, and well-preserved old center.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: terfenadine Target entity description: Terfenadine is a withdrawn second-generation antihistamine formerly used to treat allergy symptoms but discontinued due to its risk of causing serious cardiac arrhythmias.
-
A.
Fenodyree
Fenodyree is a mythical, goblin-like creature from Alan Garner’s fantasy novel "The Weirdstone of Brisingamen," known for aiding the protagonists with its otherworldly powers and knowledge of the hidden realms.
-
B.
Benadryl
Benadryl is a widely used over-the-counter antihistamine medication commonly taken to relieve allergy symptoms such as sneezing, itching, and runny nose.
-
C.
Allegra
Allegra is a widely used over-the-counter antihistamine medication for relieving allergy symptoms such as sneezing, runny nose, and itchy or watery eyes.
-
D.
Zyrtec
Zyrtec is a widely used over-the-counter antihistamine medication primarily taken to relieve allergy symptoms such as sneezing, runny nose, and itchy or watery eyes.
-
E.
Ripatransone
Ripatransone is a historic hilltop town in Italy’s Marche region, known for its medieval architecture, panoramic views, and well-preserved old center.
- F. None of above. chosen
Statements (50)
| Predicate | Object |
|---|---|
| instanceOf |
H1 receptor antagonist
ⓘ
piperidine derivative ⓘ second-generation antihistamine ⓘ withdrawn drug ⓘ |
| actsOn | histamine H1 receptor ⓘ |
| affectsIonChannel | hERG potassium channel ⓘ |
| belongsToATCClass | R06AX12 ⓘ |
| contraindicatedWith |
CYP3A4 inhibitors
ⓘ
clarithromycin ⓘ erythromycin ⓘ grapefruit juice ⓘ itraconazole ⓘ ketoconazole ⓘ |
| crossesBloodBrainBarrier | minimally ⓘ |
| developedBy | Marion Merrell Dow ⓘ |
| hasActiveMetabolite | fexofenadine ⓘ |
| hasAdverseEffect |
cardiac arrhythmia
ⓘ
dizziness ⓘ dry mouth ⓘ headache ⓘ palpitations ⓘ sedation (low incidence) ⓘ syncope ⓘ |
| hasBioavailability | low due to first-pass metabolism ⓘ |
| hasCASNumber | 50679-08-8 ⓘ |
| hasDrugBankID | DB00342 ⓘ |
| hasIUPACName | (±)-4-[1-(4-tert-butylphenyl)-4-(hydroxydiphenylmethyl)piperidin-4-ylidene]butanoic acid ⓘ |
| hasLogP | high lipophilicity ⓘ |
| hasMeltingPoint | 150-153 °C (approximate) ⓘ |
| hasMolecularFormula | C32H41NO2 ⓘ |
| hasPharmacologicalEffect |
anti-allergic effect
ⓘ
antihistamine effect ⓘ |
| hasProteinBinding | high ⓘ |
| hasPubChemCID | 5405 ⓘ |
| hasRisk |
QT interval prolongation
ⓘ
sudden cardiac death ⓘ torsades de pointes ⓘ ventricular arrhythmia ⓘ |
| hasUNIIs | 0H73WJJ391 ⓘ |
| introducedIn | 1980s ⓘ |
| isProdrugOf | fexofenadine ⓘ |
| metabolizedBy | CYP3A4 ⓘ |
| routeOfAdministration | oral ⓘ |
| usedFor |
allergic rhinitis
ⓘ
chronic idiopathic urticaria ⓘ seasonal allergic rhinitis ⓘ |
| withdrawnFromMarketIn |
European Union
ⓘ
United States ⓘ
linked to:
United States of America
|
| withdrawnIn | 1990s ⓘ |
| withdrawnReason | risk of serious cardiac arrhythmias ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: terfenadine Description of subject: Terfenadine is a withdrawn second-generation antihistamine formerly used to treat allergy symptoms but discontinued due to its risk of causing serious cardiac arrhythmias.
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.