constitutive androstane receptor
E850016
The constitutive androstane receptor (CAR) is a nuclear receptor that senses xenobiotics and endogenous compounds to regulate the expression of drug-metabolizing enzymes and transporters in the liver.
All labels observed (5)
| Label | Occurrences |
|---|---|
| constitutive androstane receptor canonical | 3 |
| NR1I subfamily | 1 |
| NR1I2 | 1 |
| nuclear receptor subfamily 1 group I member 3 | 1 |
| nuclear receptors PXR and CAR | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T10214786 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: constitutive androstane receptor Context triple: [CYP3A4, regulatedBy, constitutive androstane receptor]
-
A.
CYP3A4
CYP3A4 is a major human liver and intestinal enzyme of the cytochrome P450 family responsible for metabolizing a wide range of drugs and xenobiotics.
-
B.
CB2 receptor
The CB2 receptor is a cannabinoid receptor primarily expressed in immune and peripheral tissues, where it modulates inflammation and immune responses and serves as a key target of compounds like THC.
-
C.
CB1 receptor
The CB1 receptor is a G protein–coupled cannabinoid receptor in the brain and nervous system that mediates most of the psychoactive effects of cannabis.
-
D.
CYP2J2
CYP2J2 is a human cytochrome P450 enzyme primarily expressed in the heart and other tissues, involved in the metabolism of various drugs and endogenous fatty acids.
-
E.
CYP1A2
CYP1A2 is a liver enzyme of the cytochrome P450 family that plays a key role in the metabolism of various drugs and xenobiotics.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: constitutive androstane receptor Target entity description: The constitutive androstane receptor (CAR) is a nuclear receptor that senses xenobiotics and endogenous compounds to regulate the expression of drug-metabolizing enzymes and transporters in the liver.
-
A.
CYP3A4
CYP3A4 is a major human liver and intestinal enzyme of the cytochrome P450 family responsible for metabolizing a wide range of drugs and xenobiotics.
-
B.
CB2 receptor
The CB2 receptor is a cannabinoid receptor primarily expressed in immune and peripheral tissues, where it modulates inflammation and immune responses and serves as a key target of compounds like THC.
-
C.
CB1 receptor
The CB1 receptor is a G protein–coupled cannabinoid receptor in the brain and nervous system that mediates most of the psychoactive effects of cannabis.
-
D.
CYP2J2
CYP2J2 is a human cytochrome P450 enzyme primarily expressed in the heart and other tissues, involved in the metabolism of various drugs and endogenous fatty acids.
-
E.
CYP1A2
CYP1A2 is a liver enzyme of the cytochrome P450 family that plays a key role in the metabolism of various drugs and xenobiotics.
- F. None of above. chosen
Statements (65)
| Predicate | Object |
|---|---|
| instanceOf |
gene product
ⓘ
ligand-activated transcription factor ⓘ nuclear receptor ⓘ protein ⓘ xenobiotic sensor ⓘ |
| activatedBy |
CITCO
ⓘ
TCPOBOP ⓘ carbamazepine ⓘ endogenous metabolites ⓘ phenobarbital ⓘ phenytoin ⓘ rifampicin (human CAR) ⓘ xenobiotics ⓘ |
| alsoKnownAs |
CAR
ⓘ
NR1I3 ⓘ nuclear receptor subfamily 1 group I member 3 ⓘ
linked to:
constitutive androstane receptor
|
| belongsToFamily | nuclear receptor subfamily 1 ⓘ |
| belongsToSubfamily |
NR1I subfamily
ⓘ
linked to:
constitutive androstane receptor
|
| belongsToSuperfamily | nuclear hormone receptors ⓘ |
| bindsDNAAs | heterodimer with RXR ⓘ |
| bindsToResponseElement |
DR4-type nuclear receptor response elements
ⓘ
phenobarbital-responsive enhancer module ⓘ |
| cellularLocation |
cytoplasm
ⓘ
nucleus ⓘ |
| chromosomalLocationHuman | 1q23.3 ⓘ |
| discoveredIn | 1990s ⓘ |
| encodedByGene | NR1I3 ⓘ |
| expressedInSpecies |
Homo sapiens
ⓘ
Mus musculus ⓘ |
| expressedInTissue |
intestine
ⓘ
liver ⓘ |
| formsHeterodimerWith | retinoid X receptor alpha ⓘ |
| hasConstitutiveActivity | yes ⓘ |
| hasDomain |
DNA-binding domain
ⓘ
ligand-binding domain ⓘ |
| hasOrtholog | mouse Car (Nr1i3) ⓘ |
| hasTransactivationFunction |
AF-1 domain
ⓘ
AF-2 domain ⓘ |
| inhibitedBy |
androstanol
ⓘ
androstenol ⓘ |
| interactsWith |
coactivator PGC-1alpha
ⓘ
coactivator SRC-1 ⓘ corepressor NCoR ⓘ corepressor SMRT ⓘ |
| involvedIn |
chemical-induced liver hypertrophy
ⓘ
drug–drug interactions ⓘ xenobiotic-induced liver tumor promotion in rodents ⓘ |
| ligandType | endogenous and exogenous chemicals ⓘ |
| primarySiteOfExpression | liver ⓘ |
| regulatedBy |
nuclear translocation
ⓘ
phosphorylation ⓘ |
| regulatesBiologicalProcess |
bile acid homeostasis
ⓘ
bilirubin clearance ⓘ drug metabolism ⓘ energy metabolism ⓘ xenobiotic detoxification ⓘ |
| upregulatesExpressionOf |
ABCB1 (P-glycoprotein)
ⓘ
linked to:
P-glycoprotein
ABCC2 (MRP2) ⓘ
linked to:
ABCC2
CYP2B10 (mouse) ⓘ CYP2B6 ⓘ CYP2C9 ⓘ CYP3A4 ⓘ SLCO1B1 (OATP1B1) ⓘ SULT2A1 ⓘ UGT1A1 ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: constitutive androstane receptor Description of subject: The constitutive androstane receptor (CAR) is a nuclear receptor that senses xenobiotics and endogenous compounds to regulate the expression of drug-metabolizing enzymes and transporters in the liver.
Referenced by (7)
Full triples — surface form annotated when it differs from this entity's canonical label.
subject linked to:
pregnane X receptor
linked to: constitutive androstane receptor
linked to: constitutive androstane receptor
linked to: constitutive androstane receptor
subject linked to:
ABCG2 gene
linked to: constitutive androstane receptor