|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:DNMT1
DNA (cytosine-5)-methyltransferase 1
maintenance methyltransferase
|
|
gptkbp:associatedWith
|
gptkb:cancer
gene silencing
imprinting
epigenetic regulation
|
|
gptkbp:catalyzes
|
transfer of methyl group to cytosine
|
|
gptkbp:EC_number
|
2.1.1.37
|
|
gptkbp:encodedBy
|
DNMT1 gene
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:function
|
maintenance of DNA methylation
|
|
gptkbp:gene
|
gptkb:DNMT1
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
DNA methyltransferase 1
|
|
gptkbp:inhibitedBy
|
gptkb:5-azacytidine
gptkb:decitabine
|
|
gptkbp:interactsWith
|
gptkb:HDAC1
gptkb:PCNA
UHRF1
MeCP2
|
|
gptkbp:locatedOnChromosome
|
gptkb:19p13.2
|
|
gptkbp:location
|
gptkb:nucleus
|
|
gptkbp:molecularWeight
|
183 kDa
|
|
gptkbp:mutationAssociatedWith
|
hereditary sensory neuropathy with dementia and hearing loss
|
|
gptkbp:OMIM
|
126375
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Dnmt1
|
|
gptkbp:orthologInZebrafish
|
dnmt1
|
|
gptkbp:PDB
|
4WXX
|
|
gptkbp:postTranslationalModification
|
phosphorylation
sumoylation
ubiquitination
acetylation
|
|
gptkbp:RefSeq
|
NP_001124295.1
|
|
gptkbp:regulates
|
gptkb:X-chromosome_inactivation
gene expression
genomic imprinting
transposon silencing
|
|
gptkbp:requires
|
embryonic development
maintenance of epigenetic marks
|
|
gptkbp:reviewedBy
|
gptkb:science
gptkb:Nature_Reviews_Genetics
Cell
|
|
gptkbp:substrate
|
5-methylcytosine
|
|
gptkbp:UniProtID
|
P26358
|
|
gptkbp:bfsParent
|
gptkb:DNMT1
gptkb:decitabine
|
|
gptkbp:bfsLayer
|
8
|