|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:SK
gptkb:Dickkopf-1
gptkb:hDkk-1
gptkb:Dkk-1
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:cancer
gptkb:bone
multiple myeloma
prostate cancer
bone development
|
|
gptkbp:clinical_use
|
potential therapeutic target
biomarker for bone disease
|
|
gptkbp:discoveredBy
|
1998
|
|
gptkbp:encodes
|
gptkb:Dickkopf-related_protein_1
|
|
gptkbp:Entrez_Gene_ID
|
22943
ENSG00000107984
|
|
gptkbp:expressedIn
|
gptkb:bone
gptkb:placenta
|
|
gptkbp:fullName
|
Dickkopf WNT Signaling Pathway Inhibitor 1
|
|
gptkbp:function
|
inhibits Wnt signaling pathway
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasTranscriptVariant
|
NM_001018068.2
NM_012242.4
|
|
gptkbp:HGNC_ID
|
2899
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
DKK1 gene
|
|
gptkbp:inhibitedBy
|
gptkb:LRP5/6_co-receptors
|
|
gptkbp:interactsWith
|
gptkb:LRP5
gptkb:LRP6
Kremen1
Kremen2
|
|
gptkbp:length
|
266 amino acids
|
|
gptkbp:locatedOnChromosome
|
10
10q11.2
|
|
gptkbp:location
|
secreted
|
|
gptkbp:molecularWeight
|
28 kDa
|
|
gptkbp:mutationAssociatedWith
|
abnormal head formation in mice
|
|
gptkbp:OMIM
|
605189
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Dkk1
|
|
gptkbp:pathway
|
gptkb:Wnt_signaling_pathway
|
|
gptkbp:proteinFamily
|
Dickkopf family
|
|
gptkbp:regulates
|
bone formation
regulated by p53
osteoblast differentiation
regulated by TGF-beta
upregulated by beta-catenin
|
|
gptkbp:UniProtID
|
O94907
|
|
gptkbp:bfsParent
|
gptkb:Dickkopf-related_protein_1
gptkb:Dkk1
|
|
gptkbp:bfsLayer
|
8
|