|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:Dickkopf-1
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:bone
multiple myeloma
|
|
gptkbp:binds
|
gptkb:LRP5/6
Kremen proteins
|
|
gptkbp:decreasedIn
|
bone formation
|
|
gptkbp:discoveredIn
|
1998
|
|
gptkbp:encodedBy
|
gptkb:DKK1_gene
|
|
gptkbp:expressedIn
|
gptkb:placenta
bone tissue
various tumors
|
|
gptkbp:fullName
|
gptkb:Dickkopf-related_protein_1
|
|
gptkbp:function
|
Wnt signaling pathway inhibitor
|
|
gptkbp:gene
|
gptkb:DKK1
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Dkk-1
|
|
gptkbp:improves
|
inflammatory diseases
bone metastases
|
|
gptkbp:inhibitedBy
|
gptkb:Wnt/β-catenin_signaling
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_10q11.2
|
|
gptkbp:molecularWeight
|
28 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:zebrafish
|
|
gptkbp:PDB
|
3S2K
|
|
gptkbp:regulates
|
osteoblast differentiation
osteoclastogenesis
|
|
gptkbp:role
|
embryonic development
cancer progression
bone formation regulation
|
|
gptkbp:structure
|
secreted glycoprotein
|
|
gptkbp:target
|
therapeutic antibodies
|
|
gptkbp:UniProtID
|
O94907
|
|
gptkbp:bfsParent
|
gptkb:Dickkopf-1
|
|
gptkbp:bfsLayer
|
8
|