unfolded protein response (UPR)
GPTKB entity
Statements (23)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
cellular stress response
|
| gptkbp:alsoKnownAs |
gptkb:UPR
|
| gptkbp:component |
proteostasis network
|
| gptkbp:dysregulationAssociatedWith |
gptkb:cancer
gptkb:diabetes neurodegenerative diseases |
| gptkbp:function |
decrease protein synthesis
degrade misfolded proteins increase production of molecular chaperones restore normal function of the cell |
| https://www.w3.org/2000/01/rdf-schema#label |
unfolded protein response (UPR)
|
| gptkbp:mediatedBy |
gptkb:ATF6
gptkb:IRE1 gptkb:PERK |
| gptkbp:occurredIn |
gptkb:endoplasmic_reticulum
|
| gptkbp:regulates |
apoptosis
gene expression |
| gptkbp:relatedTo |
protein folding
cellular homeostasis endoplasmic reticulum stress |
| gptkbp:triggeredBy |
accumulation of unfolded proteins
|
| gptkbp:bfsParent |
gptkb:DDIT3
|
| gptkbp:bfsLayer |
7
|