|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:LIP
gptkb:LAP
gptkb:NF-IL6
|
|
gptkbp:alternativeSplicing
|
produces LAP and LIP isoforms
|
|
gptkbp:encodes
|
gptkb:transcription_factor
|
|
gptkbp:Entrez_Gene_ID
|
12608
|
|
gptkbp:expressedIn
|
gptkb:adipose_tissue
liver
macrophages
|
|
gptkbp:fullName
|
gptkb:CCAAT/enhancer-binding_protein_beta
|
|
gptkbp:function
|
cell differentiation
adipogenesis
regulation of immune and inflammatory responses
|
|
gptkbp:locatedOnChromosome
|
mouse chromosome 2
|
|
gptkbp:mutationAssociatedWith
|
impaired immune response
altered liver function
defective adipogenesis
reduced acute phase response
reduced macrophage function
|
|
gptkbp:organism
|
gptkb:Mus_musculus
|
|
gptkbp:orthologIn
|
CEBPB (human)
|
|
gptkbp:proteinFamily
|
gptkb:basic_leucine_zipper_(bZIP)
|
|
gptkbp:regulates
|
gptkb:TNF-alpha
gptkb:GM-CSF
gptkb:IL-10
gptkb:IL-12
gptkb:PPAR-gamma
gptkb:IL-6
apoptosis
cell cycle
hematopoiesis
gluconeogenesis
inflammatory cytokines
adipocyte differentiation
osteoclast differentiation
acute phase proteins
G-CSF
IL-1beta
M-CSF
macrophage function
C/EBP-alpha
CRP (C-reactive protein)
SAA (serum amyloid A)
expression of acute-phase response genes
|
|
gptkbp:transcription_factor_family
|
bZIP
|
|
gptkbp:transcriptional_activity
|
activator
repressor
|
|
gptkbp:UniProtID
|
P28033
|
|
gptkbp:bfsParent
|
gptkb:CEBPB_gene
|
|
gptkbp:bfsLayer
|
8
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Cebpb
|