Statements (52)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:gene
|
| gptkbp:alternativeName |
gptkb:LIP
gptkb:LAP gptkb:NF-IL6 |
| gptkbp:alternativeSplicing |
produces LAP and LIP isoforms
|
| gptkbp:encodes |
transcription factor
|
| gptkbp:Entrez_Gene_ID |
12608
|
| gptkbp:expressedIn |
liver
adipose tissue macrophages |
| gptkbp:fullName |
gptkb:CCAAT/enhancer-binding_protein_beta
|
| gptkbp:function |
cell differentiation
adipogenesis regulation of immune and inflammatory responses |
| https://www.w3.org/2000/01/rdf-schema#label |
Cebpb
|
| gptkbp:locatedOnChromosome |
mouse chromosome 2
|
| gptkbp:mutationAssociatedWith |
impaired immune response
altered liver function defective adipogenesis reduced acute phase response reduced macrophage function |
| gptkbp:organism |
gptkb:Mus_musculus
|
| gptkbp:orthologIn |
CEBPB (human)
|
| gptkbp:proteinFamily |
gptkb:basic_leucine_zipper_(bZIP)
|
| gptkbp:regulates |
gptkb:TNF-alpha
gptkb:GM-CSF gptkb:IL-10 gptkb:IL-12 gptkb:PPAR-gamma gptkb:IL-6 apoptosis cell cycle hematopoiesis gluconeogenesis inflammatory cytokines adipocyte differentiation osteoclast differentiation acute phase proteins G-CSF IL-1beta M-CSF macrophage function C/EBP-alpha CRP (C-reactive protein) SAA (serum amyloid A) expression of acute-phase response genes |
| gptkbp:transcription_factor_family |
bZIP
|
| gptkbp:transcriptional_activity |
activator
repressor |
| gptkbp:UniProtID |
P28033
|
| gptkbp:bfsParent |
gptkb:CEBPB_gene
|
| gptkbp:bfsLayer |
8
|