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gptkbp:instanceOf
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gptkb:protein
gptkb:CRISPR-Cas_system
|
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gptkbp:alternativeName
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gptkb:Cpf1
|
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gptkbp:cleavage
|
single-stranded DNA
double-stranded DNA
|
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gptkbp:compatibleWith
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gptkb:tracrRNA
|
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gptkbp:component
|
CRISPR adaptive immune system
|
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gptkbp:discoveredIn
|
2015
|
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gptkbp:foundIn
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gptkb:Bacteria
archaea
|
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gptkbp:function
|
gptkb:DNA_endonuclease
genome editing
|
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gptkbp:hasActivity
|
collateral cleavage activity
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Cas12
|
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gptkbp:mechanismOfAction
|
RNA-guided
|
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gptkbp:recognizedBy
|
PAM sequence
|
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gptkbp:relatedTo
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gptkb:Cas9
|
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gptkbp:requires
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gptkb:crRNA
|
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gptkbp:structure
|
C-terminal domain
N-terminal domain
Bridge helix
Nuc domain
PI domain
REC domain
WED domain
single RuvC domain
|
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gptkbp:subspecies
|
gptkb:Cas12a
gptkb:Cas12b
gptkb:Cas12c
gptkb:Cas12d
gptkb:Cas12e
gptkb:Cas12f
gptkb:Cas12g
gptkb:Cas12h
gptkb:Cas12i
gptkb:Cas12j
gptkb:Cas12k
gptkb:Cas12l
gptkb:Cas12m
gptkb:Cas12n
gptkb:Cas12o
gptkb:Cas12p
gptkb:Cas12q
gptkb:Cas12r
gptkb:Cas12s
gptkb:Cas12t
gptkb:Cas12u
gptkb:Cas12v
gptkb:Cas12w
gptkb:Cas12x
gptkb:Cas12y
gptkb:Cas12z
|
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gptkbp:targetRecognition
|
T-rich PAM sequence
|
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gptkbp:usedFor
|
diagnostics
gene editing
gene knockout
|
|
gptkbp:usedIn
|
gptkb:CRISPR-Cas12_system
gptkb:DETECTR_diagnostic_assay
gptkb:SHERLOCK_diagnostic_assay
COVID-19 detection
|
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gptkbp:bfsParent
|
gptkb:CRISPR-Cas9
gptkb:Cas9_protein
|
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gptkbp:bfsLayer
|
6
|