|
gptkbp:instanceOf
|
gptkb:protein
endonuclease
|
|
gptkbp:alternativeName
|
gptkb:CRISPR-associated_protein_9
|
|
gptkbp:component
|
gptkb:CRISPR-Cas_system
|
|
gptkbp:discoveredBy
|
gptkb:Emmanuelle_Charpentier
gptkb:Jennifer_Doudna
|
|
gptkbp:domain
|
gptkb:HNH_domain
gptkb:PAM-interacting_domain
gptkb:RuvC_domain
|
|
gptkbp:EC_number
|
3.1.27.9
|
|
gptkbp:foundIn
|
gptkb:Streptococcus_pyogenes
|
|
gptkbp:function
|
genome editing
DNA cleavage
|
|
gptkbp:gene
|
cas9
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Cas9
|
|
gptkbp:inhibitedBy
|
gptkb:anti-CRISPR_proteins
|
|
gptkbp:molecularWeight
|
160 kDa
|
|
gptkbp:PDB
|
gptkb:4CMP
|
|
gptkbp:recognizedBy
|
PAM sequence
|
|
gptkbp:requires
|
gptkb:guide_RNA
|
|
gptkbp:structure
|
bilobed
|
|
gptkbp:usedFor
|
gptkb:gene_drive
gptkb:single_guide_RNA_(sgRNA)
drug discovery
synthetic biology
diagnostics
gene editing
genome engineering
therapeutic genome editing
base editing
gene therapy
prime editing
disease modeling
functional genomics
crop improvement
epigenome editing
gene activation
gene knockout
gene repression
transcriptional regulation
animal model generation
targeted mutagenesis
create double-strand breaks in DNA
|
|
gptkbp:usedIn
|
gptkb:biotechnology
gptkb:medicine
gptkb:CRISPR-Cas9_technology
agriculture
molecular biology
genetic engineering
|
|
gptkbp:bfsParent
|
gptkb:CRISPR-Cas9_technology
|
|
gptkbp:bfsLayer
|
6
|