Statements (30)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
gptkb:CRISPR-Cas_system |
| gptkbp:advantage |
compact size for delivery
efficient DNA cleavage |
| gptkbp:affiliatedWith |
gptkb:Class_2_CRISPR_systems
|
| gptkbp:alternativeName |
gptkb:Cas14
gptkb:Cpf1f |
| gptkbp:application |
gptkb:gene_therapy
diagnostics in vivo genome editing |
| gptkbp:discoveredBy |
gptkb:Jennifer_Doudna_lab
|
| gptkbp:discoveredIn |
2018
|
| gptkbp:foundIn |
prokaryotes
|
| gptkbp:function |
genome editing
DNA cleavage |
| gptkbp:mechanismOfAction |
RNA-guided endonuclease activity
|
| gptkbp:molecularWeight |
~400-700 amino acids
|
| gptkbp:notableFor |
small size
|
| gptkbp:PAMRequirement |
TTTV (where V is A, C, or G)
|
| gptkbp:relatedTo |
gptkb:Cas12a
gptkb:Cas12b gptkb:Cas9 |
| gptkbp:target |
double-stranded DNA
|
| gptkbp:usedIn |
gptkb:biotechnology
genome engineering |
| gptkbp:bfsParent |
gptkb:CRISPR-Cas12_enzyme
gptkb:Cas12_protein gptkb:CRISPR-Cas12 |
| gptkbp:bfsLayer |
6
|
| https://www.w3.org/2000/01/rdf-schema#label |
Cas12f
|