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gptkbp:instanceOf
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gptkb:protein
RNA molecule
genetic engineering technology
prokaryotic immune system
genome editing tool
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gptkbp:alsoKnownAs
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gptkb:crRNA
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gptkbp:alternativeName
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CRISPR-associated_endonuclease
CRISPR-associated_protein
CRISPR-associated_protein_family
CRISPR_RNA
CRISPR_system
RNA-guided_RNA_endonuclease
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gptkbp:alternativeTo
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gptkb:RNA_interference
gptkb:TALEN
gptkb:ZFN
meganucleases
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gptkbp:application
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gptkb:biotechnology
gptkb:medicine
agriculture
gene therapy
disease modeling
functional genomics
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gptkbp:associatedWith
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gptkb:CRISPR-Cas_system
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gptkbp:class
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Class 1 CRISPR proteins
Class 2 CRISPR proteins
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gptkbp:component
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gptkb:CRISPR_array
gptkb:Cas_proteins
gptkb:CRISPR
gptkb:Cas9_protein
gptkb:crRNA
gptkb:guide_RNA
gptkb:tracrRNA
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gptkbp:controversy
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ethical concerns
germline editing
off-target effects
patent dispute
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gptkbp:derivedFrom
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gptkb:CRISPR_array
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gptkbp:discoveredBy
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gptkb:Emmanuelle_Charpentier
gptkb:Jennifer_Doudna
gptkb:Francisco_Mojica
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gptkbp:discoveredIn
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1987
2000s
2007
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gptkbp:ethicalConcern
|
bioethics
germline editing
off-target effects
designer babies
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gptkbp:firstDescribed
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gptkb:Francisco_Mojica
gptkb:Bacteria
2005
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gptkbp:foundIn
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gptkb:Bacteria
archaea
prokaryotes
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gptkbp:fullName
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gptkb:Clustered_Regularly_Interspaced_Short_Palindromic_Repeats_system
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gptkbp:function
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guides Cas proteins to target DNA
adaptive immunity in prokaryotes
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gptkbp:hasMember
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gptkb:Cpf1
gptkb:Cas3
gptkb:Cas4
Cas10
Cas11
Cas5
Cas6
Cas7
Cas8
CasX
CasY
CasZ
Csa proteins
Csb proteins
Csc proteins
Csd proteins
Cse proteins
Csh proteins
Csm6
Cst proteins
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https://www.w3.org/2000/01/rdf-schema#label
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CRISPR-Cas system
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gptkbp:includes
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gptkb:Cas9
gptkb:Cas12
gptkb:Cas13
gptkb:Cas1
gptkb:Cas2
Cmr proteins
Csm proteins
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gptkbp:interactsWith
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gptkb:Cas9
gptkb:tracrRNA
gptkb:Cas12
gptkb:Cas13
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gptkbp:length
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variable
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gptkbp:mechanismOfAction
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gptkb:syntax
interference
targeted DNA cleavage
adaptive immunity
foreign DNA recognition
spacer acquisition
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gptkbp:NobelPrizeYear
|
gptkb:2020_Nobel_Prize_in_Chemistry
gptkb:Emmanuelle_Charpentier
gptkb:Jennifer_Doudna
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gptkbp:notablePublication
|
gptkb:Jinek_et_al.,_2012
gptkb:Mojica_et_al.,_2005
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gptkbp:notableVariant
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gptkb:CRISPR-Cas3
gptkb:CRISPR-Cas12
gptkb:CRISPR-Cas13
gptkb:CRISPR-Cas9
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gptkbp:origin
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transcription of CRISPR locus
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gptkbp:partOf
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gptkb:CRISPR-Cas_system
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gptkbp:patent
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gptkb:Broad_Institute
gptkb:University_of_California
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gptkbp:patentDispute
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gptkb:Broad_Institute
gptkb:University_of_California
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gptkbp:processor
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maturation by Cas proteins
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gptkbp:regulates
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gptkb:WHO
gptkb:FDA
gptkb:NIH
gptkb:crRNA
gptkb:tracrRNA
PAM sequence
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gptkbp:relatedTo
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gptkb:Cas12_protein
gptkb:Cas13_protein
gptkb:TALEN
gptkb:ZFN
gptkb:tracrRNA
gptkb:sgRNA
gptkb:Cpf1_protein
genome engineering
adaptive immunity
RNA-guided endonuclease
bacterial defense system
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gptkbp:role
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adaptive immunity
integration of new spacers
cleavage of foreign genetic material
interference with invading nucleic acids
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gptkbp:sequence
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spacer-repeat structure
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gptkbp:studiedIn
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molecular biology
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gptkbp:usedFor
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gptkb:biotechnology
therapeutics
diagnostics
gene editing
genome editing
genome engineering
base editing
gene activation
gene knockout
gene repression
RNA targeting
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gptkbp:usedIn
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genome editing
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gptkbp:bfsParent
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gptkb:CRISPR-Cas12_enzyme
gptkb:Cas12_protein
gptkb:CRISPR-Cas12
gptkb:CRISPR_interference
gptkb:Cas9_protein
gptkb:Clustered_Regularly_Interspaced_Short_Palindromic_Repeats
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gptkbp:bfsLayer
|
6
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