|
gptkbp:instanceOf
|
gptkb:drug
analgesic
|
|
gptkbp:administeredBy
|
anesthesiologist
critical care physician
|
|
gptkbp:ATCCode
|
N01AX10
|
|
gptkbp:boilingPoint
|
256°C
|
|
gptkbp:brand
|
gptkb:Diprivan
|
|
gptkbp:CASNumber
|
2078-54-8
|
|
gptkbp:chemicalFormula
|
C12H18O
|
|
gptkbp:color
|
white (emulsion)
|
|
gptkbp:compatibleWith
|
analgesia
|
|
gptkbp:contraindication
|
allergy to egg or soy
|
|
gptkbp:discoveredBy
|
gptkb:ICI_Pharmaceuticals
|
|
gptkbp:discoveredIn
|
1977
|
|
gptkbp:duration
|
5 to 10 minutes
|
|
gptkbp:effect
|
gptkb:center
loss of consciousness
muscle relaxation
antiemetic effect
|
|
gptkbp:eliminationHalfLife
|
2 to 24 hours
|
|
gptkbp:FDAApproved
|
1989
|
|
gptkbp:form
|
oil-in-water emulsion
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
propofol
|
|
gptkbp:IUPACName
|
gptkb:2,6-diisopropylphenol
|
|
gptkbp:KEGGID
|
D08417
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:meltingPoint
|
18°C
|
|
gptkbp:MeSH_ID
|
D017052
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
178.27 g/mol
|
|
gptkbp:notableFor
|
gptkb:Michael_Jackson's_death
|
|
gptkbp:onset
|
30 seconds
|
|
gptkbp:pregnancyCategory
|
B (US)
|
|
gptkbp:PubChem_CID
|
gptkb:CHEMBL472
4943
DB00818
|
|
gptkbp:riskFactor
|
abuse potential
hypersensitivity reactions
bacterial contamination
|
|
gptkbp:routeOfAdministration
|
intravenous
|
|
gptkbp:sideEffect
|
gptkb:propofol_infusion_syndrome
hypotension
respiratory depression
pain at injection site
bradycardia
|
|
gptkbp:solubility
|
insoluble
|
|
gptkbp:solubilityInLipid
|
high
|
|
gptkbp:storage
|
protect from light
do not refrigerate
|
|
gptkbp:UNII
|
0J48LPH2TH
|
|
gptkbp:usedFor
|
induction of anesthesia
maintenance of anesthesia
sedation for mechanically ventilated adults
|
|
gptkbp:bfsParent
|
gptkb:4-aminobutanoic_acid
gptkb:Anesthesia
gptkb:CYP2B6
|
|
gptkbp:bfsLayer
|
6
|