|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:Parkinson's_disease
bipolar disorder
schizophrenia
pain sensitivity
|
|
gptkbp:cofactor
|
gptkb:S-adenosyl_methionine
|
|
gptkbp:discoveredBy
|
gptkb:Julius_Axelrod
|
|
gptkbp:discoveredIn
|
1958
|
|
gptkbp:EC_number
|
2.1.1.6
|
|
gptkbp:encodedBy
|
gptkb:COMT_gene
|
|
gptkbp:expressedIn
|
gptkb:kidney
brain
liver
red blood cells
|
|
gptkbp:fullName
|
catechol-O-methyltransferase
|
|
gptkbp:function
|
catalyzes the transfer of a methyl group to catecholamines
inactivates neurotransmitters such as dopamine, epinephrine, and norepinephrine
|
|
gptkbp:gene
|
gptkb:COMT
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasPolymorphism
|
Val158Met
|
|
gptkbp:HGNC_ID
|
2228
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
COMT
|
|
gptkbp:inhibitedBy
|
gptkb:entacapone
gptkb:tolcapone
opicapone
|
|
gptkbp:locatedOnChromosome
|
gptkb:22q11.21
|
|
gptkbp:location
|
gptkb:cell_membrane
cytosol
|
|
gptkbp:molecularWeight
|
24 kDa
|
|
gptkbp:OMIM
|
116790
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Bos_taurus
gptkb:Mus_musculus
gptkb:Pan_troglodytes
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
1H1D
1VID
3BWM
|
|
gptkbp:RefSeq
|
NM_000754
|
|
gptkbp:relatedTo
|
dopaminergic signaling
COMT deficiency
methylation of catechols
|
|
gptkbp:substrate
|
gptkb:L-DOPA
dopamine
norepinephrine
epinephrine
catechol estrogens
|
|
gptkbp:UniProtID
|
gptkb:P21964
|
|
gptkbp:bfsParent
|
gptkb:DB02546
gptkb:catechol-O-methyl_transferase
gptkb:69-53-4
|
|
gptkbp:bfsLayer
|
7
|