|
gptkbp:instanceOf
|
gptkb:chemical_compound
amino acid derivative
|
|
gptkbp:administered_with
|
benserazide
carbidopa
|
|
gptkbp:approved_drug_in
|
gptkb:European_Union
gptkb:United_States
|
|
gptkbp:ATCCode
|
N04BA01
|
|
gptkbp:biosynthesized_from
|
gptkb:L-tyrosine
|
|
gptkbp:CASNumber
|
59-92-7
|
|
gptkbp:chemicalFormula
|
C9H11NO4
|
|
gptkbp:discoveredBy
|
gptkb:Arvid_Carlsson
|
|
gptkbp:foundIn
|
gptkb:Mucuna_pruriens
gptkb:Vicia_faba
|
|
gptkbp:hasUNII
|
46627O600J
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
L-DOPA
|
|
gptkbp:is_a_neurotransmitter_precursor
|
yes
|
|
gptkbp:is_a_precursor_for
|
melanin
|
|
gptkbp:is_a_prodrug
|
yes
|
|
gptkbp:is_absorbed_in
|
gptkb:small_intestine
|
|
gptkbp:is_contraindicated_with
|
narrow-angle glaucoma
nonselective MAO inhibitors
|
|
gptkbp:is_essential_medicine
|
gptkb:World_Health_Organization
|
|
gptkbp:is_optically_active
|
yes
|
|
gptkbp:IUPACName
|
gptkb:(S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic_acid
|
|
gptkbp:mass
|
197.19 g/mol
|
|
gptkbp:meltingPoint
|
275 °C
|
|
gptkbp:metabolism
|
aromatic L-amino acid decarboxylase
catechol-O-methyltransferase
|
|
gptkbp:pKa
|
2.32
8.72
|
|
gptkbp:predecessor
|
dopamine
norepinephrine
epinephrine
|
|
gptkbp:PubChem_CID
|
gptkb:CHEBI:15765
gptkb:DB01235
6047
5822
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
nausea
hypotension
dyskinesia
hallucinations
|
|
gptkbp:substrate
|
gptkb:DOPA_decarboxylase
gptkb:large_neutral_amino_acid_transporter
gptkb:tyrosine_hydroxylase
|
|
gptkbp:synonym
|
gptkb:levodopa
gptkb:L-3,4-dihydroxyphenylalanine
|
|
gptkbp:usedFor
|
gptkb:Parkinson's_disease
dopamine-responsive dystonia
|
|
gptkbp:bfsParent
|
gptkb:Awakenings
|
|
gptkbp:bfsLayer
|
5
|