entacapone

GPTKB entity

Statements (39)
Predicate Object
gptkbp:instanceOf gptkb:drug
catechol-O-methyltransferase inhibitor
gptkbp:approvalYear 1999
gptkbp:approvedBy gptkb:FDA
gptkbp:ATCCode N04BX02
gptkbp:brand gptkb:Stalevo
gptkb:Comtan
gptkbp:CASNumber 130929-57-6
gptkbp:contraindication hepatic impairment
hypersensitivity to entacapone
gptkbp:discoveredBy gptkb:Orion_Pharma
gptkbp:drugInteraction gptkb:levodopa
gptkb:warfarin
gptkbp:eliminationHalfLife 0.4–0.7 hours
gptkbp:excretion urine
feces
gptkbp:hasMolecularFormula C14H15N3O5
https://www.w3.org/2000/01/rdf-schema#label entacapone
gptkbp:KEGGID D07913
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction inhibits catechol-O-methyltransferase
gptkbp:metabolism liver
gptkbp:pregnancyCategory C (US)
gptkbp:proteinBinding 98%
gptkbp:PubChem_CID CHEMBL1425
4445392
5281081
DB00494
gptkbp:routeOfAdministration oral
gptkbp:sideEffect nausea
diarrhea
hallucination
dyskinesia
urine discoloration
gptkbp:synonym (E)-2-cyano-N,N-diethyl-3,4-dihydroxy-5-nitrobenzenepropenamide
gptkbp:UNII 49717AWG6K
gptkbp:usedFor gptkb:Parkinson's_disease
gptkbp:bfsParent gptkb:Comtan
gptkbp:bfsLayer 6