catechol-O-methyl transferase
GPTKB entity
Statements (27)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:abbreviation |
gptkb:COMT
|
| gptkbp:cofactor |
gptkb:S-adenosyl_methionine
|
| gptkbp:discoveredBy |
gptkb:Julius_Axelrod
|
| gptkbp:discoveredIn |
1958
|
| gptkbp:EC_number |
2.1.1.6
|
| gptkbp:foundIn |
gptkb:kidney
brain liver |
| gptkbp:function |
catalyzes the transfer of a methyl group to catecholamines
|
| gptkbp:gene |
gptkb:COMT_gene
|
| gptkbp:hasPolymorphism |
Val158Met
|
| gptkbp:inhibitedBy |
gptkb:entacapone
gptkb:tolcapone |
| gptkbp:involvedIn |
catecholamine metabolism
|
| gptkbp:location |
gptkb:cell_membrane
cytosol |
| gptkbp:OMIM |
116790
|
| gptkbp:significance |
Parkinson's disease treatment
|
| gptkbp:substrate |
dopamine
norepinephrine epinephrine |
| gptkbp:UniProtID |
gptkb:P21964
|
| gptkbp:bfsParent |
gptkb:Dopamine
gptkb:Adrenaline |
| gptkbp:bfsLayer |
7
|
| https://www.w3.org/2000/01/rdf-schema#label |
catechol-O-methyl transferase
|