catechol-O-methyl transferase
GPTKB entity
Statements (27)
Predicate | Object |
---|---|
gptkbp:instanceOf |
gptkb:enzyme
|
gptkbp:abbreviation |
gptkb:COMT
|
gptkbp:cofactor |
gptkb:S-adenosyl_methionine
|
gptkbp:discoveredBy |
gptkb:Julius_Axelrod
|
gptkbp:discoveredIn |
1958
|
gptkbp:EC_number |
2.1.1.6
|
gptkbp:foundIn |
gptkb:kidney
brain liver |
gptkbp:function |
catalyzes the transfer of a methyl group to catecholamines
|
gptkbp:gene |
gptkb:COMT_gene
|
gptkbp:hasPolymorphism |
Val158Met
|
https://www.w3.org/2000/01/rdf-schema#label |
catechol-O-methyl transferase
|
gptkbp:inhibitedBy |
gptkb:entacapone
gptkb:tolcapone |
gptkbp:involvedIn |
catecholamine metabolism
|
gptkbp:location |
gptkb:cell_membrane
cytosol |
gptkbp:OMIM |
116790
|
gptkbp:significance |
Parkinson's disease treatment
|
gptkbp:substrate |
dopamine
norepinephrine epinephrine |
gptkbp:UniProtID |
gptkb:P21964
|
gptkbp:bfsParent |
gptkb:Dopamine
gptkb:Adrenaline |
gptkbp:bfsLayer |
6
|