|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:SOCS
gptkb:SOCS1
gptkb:CIS
CIS1
|
|
gptkbp:associatedWith
|
gptkb:cancer
autoimmune diseases
|
|
gptkbp:biologicalProcess
|
protein binding
SH2 domain binding
|
|
gptkbp:chromosomeArm
|
3p21.3
|
|
gptkbp:discoveredBy
|
1997
|
|
gptkbp:encodes
|
gptkb:CISH_protein
|
|
gptkbp:Entrez_Gene_ID
|
1154
ENSG00000175197
|
|
gptkbp:expressedIn
|
immune cells
|
|
gptkbp:fullName
|
Cytokine Inducible SH2 Containing Protein gene
|
|
gptkbp:function
|
negative regulation of cytokine signaling
inhibition of JAK-STAT signaling pathway
|
|
gptkbp:HGNC_ID
|
1980
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CISH gene
|
|
gptkbp:interactsWith
|
gptkb:JAK2
gptkb:STAT5
gptkb:prolactin_receptor
interleukin receptors
|
|
gptkbp:length
|
258
|
|
gptkbp:locatedOnChromosome
|
3
|
|
gptkbp:mutationAssociatedWith
|
altered immune regulation
susceptibility to autoimmune diseases
susceptibility to infectious diseases
|
|
gptkbp:OMIM
|
603597
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
mouse Cish gene
rat Cish gene
|
|
gptkbp:pathway
|
gptkb:JAK-STAT_signaling_pathway
cytokine signaling
|
|
gptkbp:proteinFamily
|
gptkb:SOCS_box
gptkb:SOCS_family
SH2 domain
|
|
gptkbp:regulates
|
gptkb:STAT5
immune response
T cell activation
interleukin signaling
prolactin signaling
macrophage activation
feedback inhibitor of cytokine signaling
natural killer cell function
transcriptionally induced by cytokines
|
|
gptkbp:transcription_induced_by
|
cytokines
|
|
gptkbp:UniProtID
|
O15524
|
|
gptkbp:bfsParent
|
gptkb:CISH_protein
gptkb:Cytokine_Inducible_SH2-containing_protein
|
|
gptkbp:bfsLayer
|
7
|