Statements (30)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alternativeName |
gptkb:CIS
gptkb:Cytokine-inducible_SH2-containing_protein |
| gptkbp:domain |
gptkb:SOCS_box
SH2 domain |
| gptkbp:encodedBy |
gptkb:CISH_gene
|
| gptkbp:Entrez_Gene_ID |
1154
|
| gptkbp:expressedIn |
gptkb:T_cells
macrophages |
| gptkbp:foundIn |
gptkb:Homo_sapiens
|
| gptkbp:function |
negative regulation of cytokine signaling
|
| https://www.w3.org/2000/01/rdf-schema#label |
CISH protein
|
| gptkbp:inhibitedBy |
gptkb:JAK-STAT_signaling_pathway
|
| gptkbp:interactsWith |
gptkb:JAK2
gptkb:STAT5 |
| gptkbp:involvedIn |
feedback inhibition of cytokine signaling
|
| gptkbp:locatedOnChromosome |
3p21.3
|
| gptkbp:memberOf |
gptkb:SOCS_family
|
| gptkbp:molecularWeight |
~28 kDa
|
| gptkbp:OMIM |
603597
|
| gptkbp:PDB |
gptkb:2C9W
|
| gptkbp:regulates |
immune response
growth hormone signaling prolactin signaling erythropoietin signaling interleukin-2 signaling |
| gptkbp:UniProtID |
O15524
|
| gptkbp:bfsParent |
gptkb:CIS_(gene)
gptkb:CISH |
| gptkbp:bfsLayer |
6
|