gptkbp:instanceOf
|
gptkb:chemical_compound
|
gptkbp:approvalYear
|
2001
|
gptkbp:approvedBy
|
gptkb:gastrointestinal_stromal_tumor
gptkb:chronic_myeloid_leukemia
|
gptkbp:ATCCode
|
L01EA01
|
gptkbp:bioavailability
|
98%
|
gptkbp:CASNumber
|
152459-95-5
|
gptkbp:developedBy
|
gptkb:Novartis
|
gptkbp:drugClass
|
inhibits BCR-ABL tyrosine kinase activity
inhibits c-Kit and PDGFR tyrosine kinases
|
gptkbp:halfLife
|
18 hours
|
gptkbp:hasBindingDBID
|
BDBM50033413
|
gptkbp:hasEliminationRoute
|
urine
feces
|
gptkbp:hasInChIKey
|
gptkb:KHGXJUYNMMXHFG-UHFFFAOYSA-N
|
gptkbp:hasMolecularFormula
|
C29H31N7O
|
gptkbp:hasPatentExpiry
|
2015 (US)
|
gptkbp:hasPDBLigandID
|
gptkb:STI
|
gptkbp:hasSMILES
|
CC1=CC=CC=C1NC(=O)C2=CC=CC=C2C(=O)N3CCN(CC3)C4=NC=CC(=N4)N
|
gptkbp:hasUNII
|
8C8O2UF0ZV
|
https://www.w3.org/2000/01/rdf-schema#label
|
CHEMBL428
|
gptkbp:legalStatus
|
prescription only
|
gptkbp:mechanismOfAction
|
gptkb:receptor_tyrosine_kinase
|
gptkbp:metabolism
|
liver
|
gptkbp:molecularWeight
|
493.6
|
gptkbp:name
|
gptkb:Imatinib
|
gptkbp:pregnancyCategory
|
D (US)
|
gptkbp:PubChem_CID
|
gptkb:CHEBI:45783
gptkb:DB00619
5291
5098
D00568
|
gptkbp:routeOfAdministration
|
oral
|
gptkbp:sideEffect
|
nausea
edema
rash
muscle cramps
|
gptkbp:synonym
|
gptkb:Gleevec
gptkb:STI-571
|
gptkbp:target
|
gptkb:BCR-ABL
gptkb:PDGFR
gptkb:c-Kit
|
gptkbp:therapeuticArea
|
oncology
|
gptkbp:bfsParent
|
gptkb:topotecan
|
gptkbp:bfsLayer
|
7
|