CHEMBL413

GPTKB entity

Statements (52)
Predicate Object
gptkbp:instanceOf gptkb:chemical_compound
gptkbp:approvalYear 1976
gptkbp:ATCCode gptkb:C07AB03
gptkbp:bioavailability 50% (oral)
gptkbp:boilingPoint not applicable (decomposes)
gptkbp:CASNumber gptkb:29122-68-7
gptkbp:color white (solid)
gptkbp:contraindication heart block
severe bradycardia
cardiogenic shock
hypersensitivity to atenolol
gptkbp:developedBy gptkb:ICI_Pharmaceuticals
gptkbp:drugClass beta blocker
gptkbp:excretion gptkb:kidney
gptkbp:halfLife 6-7 hours
gptkbp:hasInChIKey METKIMKYRPQLGS-UHFFFAOYSA-N
gptkbp:hasLogP 0.16
gptkbp:hasMolecularFormula C14H22N2O3
gptkbp:hasReceptorAffinity high for beta-1, low for beta-2
gptkbp:hasSMILES CC(C)NCC(COC1=CC=CC=C1O)O
gptkbp:hasUNII 50VV3VW0TI
https://www.w3.org/2000/01/rdf-schema#label CHEMBL413
gptkbp:indication gptkb:arrhythmia
myocardial infarction
hypertension
angina pectoris
gptkbp:isApprovedDrug true
gptkbp:KEGGID gptkb:D00222
gptkbp:legalStatus prescription only
gptkbp:listedOn gptkb:WHO_Model_List_of_Essential_Medicines
gptkbp:mechanismOfAction beta-1 adrenergic receptor antagonist
gptkbp:meltingPoint 152-155°C
gptkbp:metabolism liver
gptkbp:molecularWeight 266.34
gptkbp:name gptkb:Atenolol
gptkbp:notRecommendedFor asthma patients
gptkbp:pregnancyCategory C (US)
gptkbp:PubChem_CID 2076
2162
CHEBI:2269
DB00335
gptkbp:routeOfAdministration oral
gptkbp:sideEffect dizziness
fatigue
bradycardia
cold extremities
gptkbp:solubility water soluble
gptkbp:synonym gptkb:Atenololum
gptkb:Tenormin
gptkbp:target gptkb:Beta-1_adrenergic_receptor
gptkbp:bfsParent gptkb:ATRA
gptkbp:bfsLayer 6