|
gptkbp:instanceOf
|
gptkb:abbreviation
gptkb:chemical_compound
|
|
gptkbp:affects
|
RAR receptors
RXR receptors
|
|
gptkbp:approvedBy
|
gptkb:FDA
|
|
gptkbp:CASNumber
|
302-79-4
|
|
gptkbp:category
|
gptkb:antineoplastic_agent
gptkb:vitamin_A_derivative
gptkb:vitamin_A
|
|
gptkbp:chemicalFormula
|
C20H28O2
|
|
gptkbp:contraindication
|
pregnancy
|
|
gptkbp:discoveredIn
|
1957
|
|
gptkbp:foundIn
|
Retinoic acid pathway
|
|
gptkbp:hasSMILES
|
CC1=C(C(=CC=C1)C)C2=CC(=CC(=C2C)C)C=CC=CC=CC(=O)O
|
|
gptkbp:IUPACName
|
(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid
|
|
gptkbp:KEGGID
|
D00137
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
induces differentiation of promyelocytes
|
|
gptkbp:meltingPoint
|
180 °C
|
|
gptkbp:MeSH_ID
|
D014024
|
|
gptkbp:metabolism
|
CYP26A1
CYP26B1
CYP26C1
|
|
gptkbp:molecularWeight
|
300.44 g/mol
|
|
gptkbp:pregnancyCategory
|
X
|
|
gptkbp:producedBy
|
oxidation of retinol
|
|
gptkbp:PubChem_CID
|
gptkb:CHEMBL413
444795
DB00755
|
|
gptkbp:relatedTo
|
gptkb:vitamin_A
gptkb:isotretinoin
13-cis-retinoic acid
|
|
gptkbp:routeOfAdministration
|
oral
topical
|
|
gptkbp:sideEffect
|
headache
bone pain
dry skin
retinoic acid syndrome
|
|
gptkbp:solubility
|
insoluble in water
soluble in ethanol
soluble in DMSO
|
|
gptkbp:standsFor
|
All-trans retinoic acid
|
|
gptkbp:synonym
|
gptkb:tretinoin
|
|
gptkbp:UNII
|
5688UTC01R
|
|
gptkbp:usedFor
|
gptkb:acne_treatment
psoriasis treatment
treatment of acute promyelocytic leukemia
photoaging treatment
|
|
gptkbp:usedIn
|
dermatology
chemotherapy protocols
|
|
gptkbp:bfsParent
|
gptkb:American_Taxpayer_Relief_Act_of_2012
gptkb:all-trans_retinoic_acid
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ATRA
|