Statements (53)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:chemical_compound
abbreviation |
| gptkbp:affects |
RAR receptors
RXR receptors |
| gptkbp:approvedBy |
gptkb:FDA
|
| gptkbp:CASNumber |
302-79-4
|
| gptkbp:category |
gptkb:vitamin_A
antineoplastic agent vitamin A derivative |
| gptkbp:chemicalFormula |
C20H28O2
|
| gptkbp:contraindication |
pregnancy
|
| gptkbp:discoveredIn |
1957
|
| gptkbp:foundIn |
Retinoic acid pathway
|
| gptkbp:hasSMILES |
CC1=C(C(=CC=C1)C)C2=CC(=CC(=C2C)C)C=CC=CC=CC(=O)O
|
| https://www.w3.org/2000/01/rdf-schema#label |
ATRA
|
| gptkbp:IUPACName |
(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid
|
| gptkbp:KEGGID |
D00137
|
| gptkbp:legalStatus |
prescription only
|
| gptkbp:mechanismOfAction |
induces differentiation of promyelocytes
|
| gptkbp:meltingPoint |
180 °C
|
| gptkbp:MeSH_ID |
D014024
|
| gptkbp:metabolism |
CYP26A1
CYP26B1 CYP26C1 |
| gptkbp:molecularWeight |
300.44 g/mol
|
| gptkbp:pregnancyCategory |
X
|
| gptkbp:producedBy |
oxidation of retinol
|
| gptkbp:PubChem_CID |
gptkb:CHEMBL413
444795 DB00755 |
| gptkbp:relatedTo |
gptkb:vitamin_A
gptkb:isotretinoin 13-cis-retinoic acid |
| gptkbp:routeOfAdministration |
oral
topical |
| gptkbp:sideEffect |
headache
bone pain dry skin retinoic acid syndrome |
| gptkbp:solubility |
insoluble in water
soluble in ethanol soluble in DMSO |
| gptkbp:standsFor |
All-trans retinoic acid
|
| gptkbp:synonym |
gptkb:tretinoin
|
| gptkbp:UNII |
5688UTC01R
|
| gptkbp:usedFor |
acne treatment
psoriasis treatment treatment of acute promyelocytic leukemia photoaging treatment |
| gptkbp:usedIn |
dermatology
chemotherapy protocols |
| gptkbp:bfsParent |
gptkb:American_Taxpayer_Relief_Act_of_2012
|
| gptkbp:bfsLayer |
5
|