Tacrolimus

GPTKB entity

Statements (56)
Predicate Object
gptkbp:instanceOf immunosuppressant
macrolide lactone
gptkbp:administeredBy oral
topical
intravenous
gptkbp:approvedBy gptkb:FDA
1994
gptkbp:ATCCode L04AD02
gptkbp:brand gptkb:Prograf
gptkb:Protopic
gptkbp:CASNumber 104987-11-3
gptkbp:chemicalFormula C44H69NO12
gptkbp:contraindication hypersensitivity to tacrolimus
gptkbp:discoveredBy gptkb:Fujisawa_Pharmaceutical_Co.
gptkbp:discoveredIn 1987
gptkbp:eliminationHalfLife 8-12 hours
https://www.w3.org/2000/01/rdf-schema#label Tacrolimus
gptkbp:interactsWith gptkb:milk
gptkb:cyclosporine
gptkb:phenytoin
gptkb:rifampin
gptkb:erythromycin
gptkb:ketoconazole
gptkb:St._John's_Wort
CYP3A4 inhibitors
phenobarbital
CYP3A4 inducers
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction immunosuppressant
gptkbp:metabolism gptkb:CYP3A4
liver
gptkbp:molecularWeight 822.03 g/mol
gptkbp:origin gptkb:Streptomyces_tsukubaensis
gptkbp:pregnancyCategory C (US)
gptkbp:PubChem_CID gptkb:CHEMBL413
445643
DB00864
gptkbp:riskFactor increased risk of skin cancer
increased risk of lymphoma
gptkbp:routeOfAdministration oral
topical
intravenous
gptkbp:sideEffect headache
hypertension
tremor
nephrotoxicity
neurotoxicity
hyperglycemia
increased risk of infection
gptkbp:storage store at 20-25°C (68-77°F)
gptkbp:UNII WMV4N1HTXA
gptkbp:usedFor prevention of organ transplant rejection
treatment of atopic dermatitis
treatment of eczema
gptkbp:bfsParent gptkb:Streptomyces_species
gptkbp:bfsLayer 6