Statements (48)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:DNA
|
| gptkbp:alias |
gptkb:CHK2
h CHe K2 |
| gptkbp:associated_with |
gptkb:disease
gptkb:familial_adenomatous_polyposis gptkb:hereditary_diffuse_gastric_cancer gptkb:hereditary_nonpolyposis_colorectal_cancer gptkb:Oncology gptkb:hereditary_breast_and_ovarian_cancer_syndrome gptkb:non-Hodgkin_lymphoma gptkb:pancreatic_cancer gptkb:Li-Fraumeni_syndrome gptkb:neuroblastoma ovarian cancer endometrial cancer stomach cancer esophageal cancer bladder cancer breast-ovarian cancer syndrome familial breast cancer hereditary breast cancer hereditary melanoma hereditary pancreatic cancer hereditary prostate cancer hereditary renal cancer |
| gptkbp:clinical_trial |
high-risk variant
|
| gptkbp:code |
checkpoint kinase 2 protein
|
| gptkbp:discovered_by |
gptkb:1996
|
| gptkbp:function |
tumor suppressor
|
| gptkbp:genetic_studies |
missense mutation
nonsense mutation deletion mutation |
| https://www.w3.org/2000/01/rdf-schema#label |
CHEK2 gene
|
| gptkbp:initiated_by |
cellular proliferation
p53 pathway |
| gptkbp:involved_in |
cellular response to stress
cellular senescence cellular response to DNA damage |
| gptkbp:located_in |
human chromosome 22
|
| gptkbp:pathway |
DNA damage response
apoptosis cell cycle regulation |
| gptkbp:promoter |
gptkb:CHEK2
|
| gptkbp:research_importance |
genetic testing
DNA repair mechanisms breast cancer susceptibility |
| gptkbp:bfsParent |
gptkb:CHK2
|
| gptkbp:bfsLayer |
6
|