|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:KIP2
gptkb:p57KIP2
CDI
|
|
gptkbp:associatedWith
|
gptkb:IMAGe_syndrome
gptkb:Beckwith-Wiedemann_syndrome
gptkb:Silver-Russell_syndrome
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000129757
1028
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:fullName
|
gptkb:Cyclin-dependent_kinase_inhibitor_1C
|
|
gptkbp:function
|
negative regulator of cell proliferation
cell cycle inhibitor
|
|
gptkbp:gene
|
gptkb:CDKN1C
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
1786
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CDKN1C (human)
|
|
gptkbp:imprinted_gene
|
yes
|
|
gptkbp:inhibitedBy
|
G1 cyclin/CDK complexes
|
|
gptkbp:interactsWith
|
gptkb:cyclin_D1
gptkb:CDK2
gptkb:CDK4
gptkb:PCNA
|
|
gptkbp:length
|
316 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:11p15.5
|
|
gptkbp:molecularWeight
|
32 kDa
|
|
gptkbp:mutationAssociatedWith
|
overgrowth syndromes
growth restriction
|
|
gptkbp:OMIM
|
600856
|
|
gptkbp:orthologInMouse
|
gptkb:Cdkn1c
|
|
gptkbp:pathway
|
cell cycle regulation
cellular senescence
p53 signaling pathway
|
|
gptkbp:postTranslationalModification
|
phosphorylation
|
|
gptkbp:regulates
|
apoptosis
cell differentiation
cell cycle arrest
imprinted, maternally expressed
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:transcriptional_regulation
|
regulated by methylation
regulated by KCNQ1OT1
regulated by PLAGL1
|
|
gptkbp:UniProtID
|
gptkb:P49918
|
|
gptkbp:bfsParent
|
gptkb:Cdkn1c
|
|
gptkbp:bfsLayer
|
7
|