|
gptkbp:instanceOf
|
gptkb:monoclonal_antibody
|
|
gptkbp:administeredBy
|
intravenous injection
|
|
gptkbp:alsoKnownAs
|
gptkb:muromonab-CD3
|
|
gptkbp:approvalYear
|
1986
|
|
gptkbp:approvedBy
|
gptkb:FDA
|
|
gptkbp:ATCCode
|
L04AA01
|
|
gptkbp:bindingSite
|
epsilon chain of CD3 complex
|
|
gptkbp:compatibleWith
|
prophylactic use in all transplants
|
|
gptkbp:discontinued
|
gptkb:United_States
2010
|
|
gptkbp:firstMonoclonalAntibodyApproved
|
true
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
OKT3
|
|
gptkbp:immunogenicity
|
can induce human anti-mouse antibodies (HAMA)
|
|
gptkbp:indication
|
acute rejection of heart transplant
acute rejection of kidney transplant
acute rejection of liver transplant
|
|
gptkbp:macromoleculeType
|
IgG2a kappa
|
|
gptkbp:mechanismOfAction
|
T cell depletion
blocks T cell activation
|
|
gptkbp:producedBy
|
Ortho Biotech
|
|
gptkbp:sideEffect
|
fever
headache
anaphylaxis
chills
cytokine release syndrome
|
|
gptkbp:species
|
gptkb:mouse
|
|
gptkbp:target
|
CD3 receptor
|
|
gptkbp:usedFor
|
immunosuppression
prevention of organ transplant rejection
|
|
gptkbp:bfsParent
|
gptkb:CD3E
|
|
gptkbp:bfsLayer
|
7
|