|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:B7-H1
PD-L1
|
|
gptkbp:discoveredIn
|
1999
|
|
gptkbp:encodedBy
|
gptkb:CD274_gene
|
|
gptkbp:Entrez_Gene_ID
|
29126
|
|
gptkbp:expressedIn
|
various tissues
tumor cells
antigen-presenting cells
|
|
gptkbp:function
|
immune checkpoint protein
inhibits T-cell activation
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
17635
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CD274
|
|
gptkbp:inhibitedBy
|
cytokine production
T-cell proliferation
cytotoxic activity
|
|
gptkbp:interactsWith
|
gptkb:PD-1
|
|
gptkbp:locatedOnChromosome
|
gptkb:9p24.1
gptkb:chromosome_9
|
|
gptkbp:location
|
gptkb:cell_membrane
|
|
gptkbp:modulatedBy
|
immune response
|
|
gptkbp:molecularWeight
|
33 kDa
|
|
gptkbp:OMIM
|
605402
|
|
gptkbp:orthologIn
|
gptkb:Bos_taurus
gptkb:Danio_rerio
gptkb:Gallus_gallus
gptkb:Mus_musculus
gptkb:Canis_lupus_familiaris
gptkb:Rattus_norvegicus
|
|
gptkbp:overexpressedIn
|
many cancers
|
|
gptkbp:partOf
|
gptkb:B7_protein_family
|
|
gptkbp:postTranslationalModification
|
glycosylation
|
|
gptkbp:regulates
|
gptkb:interferon_gamma
inflammatory cytokines
|
|
gptkbp:role
|
tumor immune evasion
autoimmune disease regulation
|
|
gptkbp:significance
|
prognostic marker in cancer
biomarker for immunotherapy
predictive marker for checkpoint inhibitor response
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:structure
|
type I transmembrane protein
|
|
gptkbp:target
|
gptkb:durvalumab
gptkb:atezolizumab
gptkb:pembrolizumab
gptkb:nivolumab
gptkb:avelumab
immunotherapy drugs
|
|
gptkbp:UniProtID
|
Q9NZQ7
|
|
gptkbp:bfsParent
|
gptkb:9p24.1
gptkb:tumor_necrosis_factor_receptor_superfamily
gptkb:RUNX1
gptkb:programmed_death-ligand_1
gptkb:programmed_death-ligand_1_(PD-L1)
gptkb:avelumab
|
|
gptkbp:bfsLayer
|
7
|