Statements (33)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:gene
|
| gptkbp:alsoKnownAs |
gptkb:B7-H1
PD-L1 CD274 molecule |
| gptkbp:associatedWith |
gptkb:cancer
autoimmune diseases |
| gptkbp:discoveredIn |
1999
|
| gptkbp:encodes |
Programmed death-ligand 1
|
| gptkbp:Entrez_Gene_ID |
29126
ENSG00000120217 |
| gptkbp:expressedIn |
immune cells
tumor cells |
| gptkbp:function |
immune checkpoint regulation
inhibition of T-cell activation |
| gptkbp:geneType |
protein-coding
|
| gptkbp:hasTranscriptVariant |
multiple
|
| gptkbp:HGNC_ID |
17635
|
| https://www.w3.org/2000/01/rdf-schema#label |
CD274 gene
|
| gptkbp:interactsWith |
PD-1 receptor
|
| gptkbp:locatedOnChromosome |
gptkb:9p24.1
gptkb:chromosome_9 |
| gptkbp:mutationAssociatedWith |
immune evasion
tumor progression |
| gptkbp:OMIM |
605402
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:product |
PD-L1 protein
|
| gptkbp:regulates |
immune response
|
| gptkbp:target |
immunotherapy
checkpoint inhibitors |
| gptkbp:UniProtID |
Q9NZQ7
|
| gptkbp:bfsParent |
gptkb:programmed_death-ligand_1
gptkb:programmed_death-ligand_1_(PD-L1) |
| gptkbp:bfsLayer |
7
|