Statements (57)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:DNA
|
| gptkbp:associated_with |
gptkb:hepatitis_B_virus
gptkb:Oncology gptkb:hepatitis_C_virus immune response autoimmune diseases chronic infections HIV infection tumor-infiltrating lymphocytes |
| gptkbp:code |
PD-L1 protein
|
| gptkbp:discovered_by |
1990s
|
| gptkbp:has_function |
immune checkpoint
|
| gptkbp:has_role |
immune tolerance
inflammatory responses T-cell exhaustion programmed cell death immune escape mechanisms |
| gptkbp:has_variants |
SNPs
|
| https://www.w3.org/2000/01/rdf-schema#label |
CD274 gene
|
| gptkbp:influences |
cell differentiation
therapeutic strategies vaccine efficacy therapeutic outcomes metastasis autoimmunity transplant rejection tumor progression therapeutic resistance immune checkpoint blockade immune surveillance tumor microenvironment remodeling |
| gptkbp:interacts_with |
PD-1 receptor
|
| gptkbp:involved_in |
cell proliferation
cell signaling pathways tumor microenvironment cancer immunotherapy cytokine signaling tumor evasion |
| gptkbp:is_expressed_in |
gptkb:Cell
B cells macrophages dendritic cells tumor cells |
| gptkbp:is_linked_to |
gptkb:disease
gptkb:Oncology ovarian cancer esophageal cancer head and neck cancer neuroendocrine tumors |
| gptkbp:is_studied_in |
clinical trials
|
| gptkbp:is_subject_to |
regulatory mechanisms
|
| gptkbp:is_targeted_at |
monoclonal antibodies
|
| gptkbp:known_as |
gptkb:PD-L1
|
| gptkbp:located_in |
human chromosome 9
|
| gptkbp:regulates |
T-cell activation
|
| gptkbp:bfsParent |
gptkb:PD-L1
|
| gptkbp:bfsLayer |
6
|