Statements (27)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:binds |
gptkb:CD28
gptkb:CTLA-4 gptkb:PD-1 |
| gptkbp:contains |
gptkb:B7-H3
gptkb:B7-H6 B7-H4 B7-1 (CD80) B7-2 (CD86) B7-H1 (PD-L1) B7-DC (PD-L2) B7-H2 (ICOSLG) B7-H5 (VISTA) B7-H7 (HHLA2) |
| gptkbp:discoveredIn |
1990s
|
| gptkbp:expressedIn |
antigen-presenting cells
|
| gptkbp:function |
immune system regulation
|
| https://www.w3.org/2000/01/rdf-schema#label |
B7 protein family
|
| gptkbp:memberOf |
gptkb:immunoglobulin_superfamily
|
| gptkbp:relatedTo |
immunotherapy
autoimmune diseases transplant rejection |
| gptkbp:role |
T cell activation
immune checkpoint regulation T cell inhibition |
| gptkbp:bfsParent |
gptkb:CD274
|
| gptkbp:bfsLayer |
8
|