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gptkbp:instanceOf
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gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:RNF55
Casitas B-lineage lymphoma proto-oncogene protein
Cbl proto-oncogene protein
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gptkbp:discoveredBy
|
Oren et al.
|
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gptkbp:domain
|
SH2 domain
RING finger domain
proline-rich region
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gptkbp:encodedBy
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gptkb:CBL_gene
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gptkbp:Entrez_Gene_ID
|
gptkb:CBL
ENSG00000110395
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gptkbp:expressedIn
|
various tissues
hematopoietic cells
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gptkbp:foundIn
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gptkb:Homo_sapiens
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gptkbp:function
|
gptkb:E3_ubiquitin-protein_ligase
|
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gptkbp:HGNC_ID
|
1541
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CBL (protein)
|
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gptkbp:interactsWith
|
gptkb:EGFR
gptkb:Vav1
gptkb:PI3K
gptkb:Fyn
gptkb:Crk
gptkb:Sos1
gptkb:ZAP-70
gptkb:Lyn
gptkb:GRB2
|
|
gptkbp:involvedIn
|
signal transduction
|
|
gptkbp:locale
|
gptkb:cytoplasm
gptkb:plasma_membrane
endosomes
|
|
gptkbp:locatedOnChromosome
|
11q23.3
|
|
gptkbp:molecularWeight
|
~120 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:Noonan_syndrome-like_disorder
leukemia
|
|
gptkbp:OMIM
|
165360
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
|
|
gptkbp:PDB
|
1FBV
|
|
gptkbp:phosphorylates
|
tyrosine residues
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
|
|
gptkbp:RefSeq
|
NP_005179.2
|
|
gptkbp:regulates
|
tyrosine kinase signaling
|
|
gptkbp:role
|
oncogenesis
hematopoiesis
T cell receptor signaling
negative regulation of receptor tyrosine kinase signaling
|
|
gptkbp:UniProtID
|
P22681
|
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gptkbp:bfsParent
|
gptkb:CBL
|
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gptkbp:bfsLayer
|
7
|