FOXO transcription factor DAF-16
GPTKB entity
Statements (50)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:activatedBy |
reduced insulin/IGF-1 signaling
|
| gptkbp:encodedBy |
daf-16 gene
|
| gptkbp:foundIn |
gptkb:Caenorhabditis_elegans
|
| gptkbp:function |
transcription factor
stress response metabolic regulation regulation of longevity |
| gptkbp:gene |
gptkb:daf-16
|
| https://www.w3.org/2000/01/rdf-schema#label |
FOXO transcription factor DAF-16
|
| gptkbp:inhibitedBy |
insulin/IGF-1 signaling
|
| gptkbp:location |
gptkb:nucleus
|
| gptkbp:orthologIn |
gptkb:human_FOXO1
gptkb:human_FOXO3 gptkb:human_FOXO4 gptkb:human_FOXO6 FOXO family proteins |
| gptkbp:participatedIn |
insulin signaling pathway
stress response pathway dauer formation pathway |
| gptkbp:phosphorylates |
gptkb:AKT_kinase
|
| gptkbp:regulates |
apoptosis
gene expression heat shock proteins immune response autophagy cell cycle arrest fat metabolism antioxidant genes dauer formation lifespan extension stress resistance oxidative stress response genes DNA repair genes antimicrobial peptide genes catalase genes cellular homeostasis genes detoxification genes gluconeogenesis genes glycogen metabolism genes innate immunity genes lipid metabolism genes metabolic enzyme genes proteostasis genes small heat shock protein genes superoxide dismutase genes xenobiotic response genes |
| gptkbp:UniProtID |
Q9U1N6
|
| gptkbp:bfsParent |
gptkb:C._elegans_DAF-16
|
| gptkbp:bfsLayer |
7
|