Statements (51)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:gene
|
| gptkbp:alternativeName |
Aspartyl protease 2
Beta-site APP-cleaving enzyme 1 Memapsin-2 |
| gptkbp:associatedWith |
gptkb:Alzheimer's_disease
|
| gptkbp:cleavage |
neuregulin-1
amyloid precursor protein (APP) seizure protein 6 (SEZ6) voltage-gated sodium channel beta-2 subunit |
| gptkbp:clinicalTrialPhase |
Alzheimer's disease therapies
|
| gptkbp:discoveredBy |
Vassar et al., 1999
|
| gptkbp:encodes |
Beta-secretase 1 protein
|
| gptkbp:Entrez_Gene_ID |
gptkb:ENSG00000186318
23621 |
| gptkbp:expressedIn |
gptkb:skeletal_muscle
brain pancreas |
| gptkbp:fullName |
gptkb:Beta-secretase_1
|
| gptkbp:function |
involved in the generation of beta-amyloid peptides
encodes an aspartic protease involved in amyloid precursor protein processing |
| gptkbp:GO_term |
GO:0007268 (synaptic transmission)
GO:0006508 (proteolysis) GO:0004190 (aspartic-type endopeptidase activity) |
| gptkbp:HGNC_ID |
933
|
| gptkbp:involvedIn |
amyloidogenic pathway
|
| gptkbp:length |
501 amino acids
|
| gptkbp:locatedOnChromosome |
chromosome 11
11q23.3 |
| gptkbp:mutationAssociatedWith |
may alter risk of Alzheimer's disease
|
| gptkbp:OMIM |
605262
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:orthologIn |
Mus musculus (mouse)
Danio rerio (zebrafish) Rattus norvegicus (rat) |
| gptkbp:pathway |
KEGG hsa05010 (Alzheimer's disease)
Reactome R-HSA-977225 (Amyloid fiber formation) UniPathway UPA00196 (Amyloid precursor protein processing) |
| gptkbp:product |
type I transmembrane protein
|
| gptkbp:proteinFamily |
gptkb:peptidase_A1_family
|
| gptkbp:regulates |
expression increased in Alzheimer's disease brains
expression regulated by hypoxia expression regulated by oxidative stress |
| gptkbp:subcellularLocation |
gptkb:endosome
gptkb:cell_membrane gptkb:Golgi_apparatus cell surface |
| gptkbp:target |
BACE1 inhibitors
|
| gptkbp:UniProtID |
P56817
|
| gptkbp:bfsParent |
gptkb:BACE1
|
| gptkbp:bfsLayer |
8
|
| https://www.w3.org/2000/01/rdf-schema#label |
BACE1 gene
|