beta-site APP-cleaving enzyme 1
GPTKB entity
Statements (21)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
gptkb:enzyme |
| gptkbp:alsoKnownAs |
gptkb:BACE1
beta-secretase 1 |
| gptkbp:associatedWith |
gptkb:Alzheimer's_disease
|
| gptkbp:biologicalProcess |
aspartic endopeptidase activity
|
| gptkbp:cellularComponent |
gptkb:cell_membrane
|
| gptkbp:discoveredIn |
1999
|
| gptkbp:encodedBy |
gptkb:BACE1_gene
|
| gptkbp:enzymeCommissionNumber |
EC 3.4.2.5
|
| gptkbp:expressedIn |
brain
pancreas |
| gptkbp:function |
cleaves amyloid precursor protein (APP)
involved in amyloid-beta peptide generation |
| https://www.w3.org/2000/01/rdf-schema#label |
beta-site APP-cleaving enzyme 1
|
| gptkbp:inhibitedBy |
BACE inhibitors
|
| gptkbp:locatedIn |
gptkb:human_chromosome_11
|
| gptkbp:species |
gptkb:Homo_sapiens
|
| gptkbp:UniProtID |
P56817
|
| gptkbp:bfsParent |
gptkb:BACE1
|
| gptkbp:bfsLayer |
8
|