Statements (28)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:alsoKnownAs |
gptkb:BACE1
beta-site APP cleaving enzyme 1 |
| gptkbp:biologicalProcess |
aspartic protease activity
|
| gptkbp:discoveredIn |
1999
|
| gptkbp:EC_number |
3.4.23.46
|
| gptkbp:encodedBy |
gptkb:BACE1_gene
|
| gptkbp:Entrez_Gene_ID |
GC11M117411
|
| gptkbp:expressedIn |
gptkb:skeletal_muscle
brain pancreas |
| gptkbp:foundIn |
gptkb:Homo_sapiens
|
| gptkbp:function |
cleaves amyloid precursor protein (APP)
|
| https://www.w3.org/2000/01/rdf-schema#label |
Beta-secretase 1
|
| gptkbp:inhibitedBy |
BACE inhibitors
|
| gptkbp:involvedIn |
amyloid-beta peptide generation
|
| gptkbp:involves |
gptkb:Alzheimer's_disease
|
| gptkbp:locatedOnChromosome |
chromosome 11q23.3
|
| gptkbp:location |
gptkb:cell_membrane
|
| gptkbp:OMIM |
605099
|
| gptkbp:orthologIn |
gptkb:Mus_musculus
gptkb:Rattus_norvegicus |
| gptkbp:structure |
type I transmembrane protein
|
| gptkbp:substrate |
amyloid precursor protein (APP)
several other membrane proteins |
| gptkbp:UniProtID |
P56817
|
| gptkbp:bfsParent |
gptkb:BACE1
|
| gptkbp:bfsLayer |
8
|