B-cell ALL

GPTKB entity

Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:disease
leukemia
gptkbp:affects gptkb:B_lymphocytes
adults
blood
bone marrow
gptkbp:canHaveGeneticAbnormality gptkb:t(9;22)_Philadelphia_chromosome
hyperdiploidy
hypodiploidy
t(12;21)
gptkbp:cause gptkb:anemia
thrombocytopenia
leukopenia
leukocytosis
gptkbp:commonIn children
gptkbp:diagnosedBy bone marrow biopsy
blood tests
immunophenotyping
flow cytometry
gptkbp:firstDescribed 20th century
https://www.w3.org/2000/01/rdf-schema#label B-cell ALL
gptkbp:ICD-10_code gptkb:C91.0
gptkbp:marking gptkb:CD22
gptkb:CD10
gptkb:TdT
gptkb:CD19
gptkb:PAX5
gptkbp:mayInclude central nervous system
liver
lymph nodes
spleen
gptkbp:MeSH_ID D015452
gptkbp:prognosis generally good in children
worse in adults
gptkbp:relapseRisk higher in adults
lower in children
gptkbp:subspecies leukemia
gptkbp:symptom fever
bleeding
fatigue
recurrent infections
bone pain
easy bruising
gptkbp:treatment chemotherapy
immunotherapy
gene therapy
corticosteroids
stem cell transplant
gptkbp:bfsParent gptkb:leukemia
gptkbp:bfsLayer 5