t(9;22) Philadelphia chromosome
GPTKB entity
Statements (24)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
chromosomal band
|
| gptkbp:alsoKnownAs |
gptkb:Philadelphia_chromosome
Ph chromosome |
| gptkbp:associatedWith |
gptkb:chronic_myeloid_leukemia
leukemia |
| gptkbp:breakpointOnChromosome22 |
q11
|
| gptkbp:breakpointOnChromosome9 |
q34
|
| gptkbp:chromosomesInvolved |
gptkb:chromosome_9
chromosome 22 |
| gptkbp:consequence |
constitutive tyrosine kinase activity
|
| gptkbp:cytogeneticNotation |
t(9;22)(q34;q11)
|
| gptkbp:diagnosticMarkerFor |
gptkb:chronic_myeloid_leukemia
|
| gptkbp:discoveredBy |
David Hungerford
Peter Nowell |
| gptkbp:discoveredIn |
1960
|
| gptkbp:frequencyInCML |
>90%
|
| gptkbp:fusionGeneCreated |
BCR-ABL1
|
| https://www.w3.org/2000/01/rdf-schema#label |
t(9;22) Philadelphia chromosome
|
| gptkbp:locationOfABL1Gene |
gptkb:chromosome_9
|
| gptkbp:locationOfBCRGene |
chromosome 22
|
| gptkbp:translocationType |
reciprocal translocation
|
| gptkbp:treatmentTarget |
tyrosine kinase inhibitors
|
| gptkbp:bfsParent |
gptkb:B-cell_ALL
|
| gptkbp:bfsLayer |
6
|