acute lymphoblastic leukemia (ALL)

URI: https://gptkb.org/entity/acute_lymphoblastic_leukemia_(ALL)
GPTKB entity
Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:disease
leukemia
gptkbp:abbreviation ALL
gptkbp:affects adults
blood
bone marrow
lymphoid lineage
gptkbp:canBePrevented no known prevention
gptkbp:cause gptkb:anemia
hepatosplenomegaly
lymphadenopathy
thrombocytopenia
leukopenia
gptkbp:commonIn children
gptkbp:diagnosedBy blood test
bone marrow biopsy
cytogenetic analysis
flow cytometry
gptkbp:firstDescribed 1845
gptkbp:hasGeneticAlteration gptkb:t(12;21)_translocation
gptkb:t(9;22)_translocation
gptkb:Philadelphia_chromosome
gptkbp:hasRelapse yes
https://www.w3.org/2000/01/rdf-schema#label acute lymphoblastic leukemia (ALL)
gptkbp:ICD-10_code gptkb:C91.0
gptkbp:incidence most common childhood cancer
gptkbp:mayInclude central nervous system
testes
gptkbp:mortalityRate higher in adults
gptkbp:originatedIn gptkb:lymphoblast
gptkbp:prognosis varies by age and genetics
gptkbp:relapseRate higher in adults
gptkbp:remissionRate high in children
gptkbp:riskFactor gptkb:Down_syndrome
radiation exposure
genetic predisposition
gptkbp:subspecies gptkb:B-cell_ALL
gptkb:T-cell_ALL
gptkbp:symptom fever
bleeding
fatigue
bone pain
frequent infections
gptkbp:treatment radiation therapy
chemotherapy
immunotherapy
targeted therapy
stem cell transplant
gptkbp:bfsParent gptkb:pre-B-cell_leukemia
gptkbp:bfsLayer 6