Statements (29)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:aminoAcidChange |
Arg158
Cys112 |
| gptkbp:associatedWith |
normal lipid metabolism
|
| gptkbp:binds |
gptkb:heparan_sulfate_proteoglycans
gptkb:LDL_receptor |
| gptkbp:discoveredBy |
gptkb:Robert_W._Mahley
|
| gptkbp:discoveredIn |
1970s
|
| gptkbp:distinctFrom |
gptkb:ApoE2
gptkb:ApoE4 |
| gptkbp:encodedBy |
gptkb:APOE_gene
|
| gptkbp:frequency |
most common ApoE isoform
|
| gptkbp:fullName |
Apolipoprotein E3
|
| gptkbp:function |
cholesterol metabolism
lipid transport |
| https://www.w3.org/2000/01/rdf-schema#label |
ApoE3
|
| gptkbp:location |
gptkb:plasma
cerebrospinal fluid |
| gptkbp:molecularWeight |
34 kDa
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:postTranslationalModification |
phosphorylation
glycosylation |
| gptkbp:role |
not associated with increased cardiovascular risk
protective against Alzheimer's disease |
| gptkbp:sequence |
299 amino acids
|
| gptkbp:structure |
contains N-terminal and C-terminal domains
|
| gptkbp:bfsParent |
gptkb:Apo-E
gptkb:ApoE |
| gptkbp:bfsLayer |
7
|