|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:affects
|
gptkb:synaptic_plasticity
cognitive decline
lipid metabolism
response to brain injury
response to statin therapy
inflammation
tau pathology
blood-brain barrier integrity
glucose metabolism in brain
|
|
gptkbp:aminoAcidChange
|
C112R
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
|
|
gptkbp:discoveredIn
|
1970s
|
|
gptkbp:distinctFrom
|
gptkb:ApoE2
gptkb:ApoE3
|
|
gptkbp:encodedBy
|
gptkb:APOE_gene
|
|
gptkbp:foundIn
|
humans
|
|
gptkbp:frequency
|
~15% worldwide
African and Northern European populations
|
|
gptkbp:fullName
|
Apolipoprotein E4
|
|
gptkbp:hasAllele
|
ε4
|
|
gptkbp:hasOMIMEntry
|
107741
|
|
gptkbp:hasPolymorphism
|
gptkb:rs429358
|
|
gptkbp:hasUniProtEntry
|
P02649
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ApoE4
|
|
gptkbp:impact
|
neuronal repair
amyloid-beta aggregation
cholesterol transport
|
|
gptkbp:increasesRiskBy
|
3-12 fold for Alzheimer's disease
|
|
gptkbp:isAlleleOf
|
gptkb:APOE_gene
|
|
gptkbp:length
|
299
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_19
|
|
gptkbp:lowestFrequencyIn
|
gptkb:East_Asian_populations
|
|
gptkbp:molecularWeight
|
34 kDa
|
|
gptkbp:PDB
|
gptkb:1LE2
|
|
gptkbp:riskFactor
|
gptkb:cardiovascular_disease
gptkb:late-onset_Alzheimer's_disease
|
|
gptkbp:structureType
|
gptkb:protein
|
|
gptkbp:usedIn
|
genetic testing for Alzheimer's risk
|
|
gptkbp:bfsParent
|
gptkb:Apo-E
gptkb:ApoE
|
|
gptkbp:bfsLayer
|
7
|