Acute lymphoblastic leukaemia

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:disease leukemia
gptkbp:affects	adults blood bone marrow lymphoid progenitor cells
gptkbp:clinicalTrialPhase	gene therapy
gptkbp:commonIn	children
gptkbp:complication	gptkb:anemia infection thrombocytopenia organ infiltration
gptkbp:diagnosedBy	blood test bone marrow biopsy
gptkbp:firstDescribed	early 20th century
gptkbp:guidanceSystem	gptkb:NCCN_Guidelines gptkb:WHO_Classification
gptkbp:hasBiomarker	gptkb:CD10 gptkb:TdT gptkb:Philadelphia_chromosome gptkb:CD19
gptkbp:hasEpidemiology	peak incidence ages 2-5
gptkbp:hasGeneticAlteration	gptkb:t(12;21)_translocation gptkb:t(9;22)_Philadelphia_chromosome hyperdiploidy hypodiploidy
https://www.w3.org/2000/01/rdf-schema#label	Acute lymphoblastic leukaemia
gptkbp:ICD-10_code	gptkb:C91.0
gptkbp:incidence	most common childhood cancer
gptkbp:mortalityRate	higher in adults
gptkbp:prognosis	variable better in children
gptkbp:riskFactor	genetic disorders radiation exposure previous chemotherapy
gptkbp:subspecies	gptkb:B-cell_ALL gptkb:T-cell_ALL
gptkbp:symptom	fever bleeding fatigue bone pain pallor
gptkbp:synonym	ALL
gptkbp:treatment	radiation therapy chemotherapy targeted therapy stem cell transplant
gptkbp:bfsParent	gptkb:C91.0
gptkbp:bfsLayer	6