|
gptkbp:instanceOf
|
gptkb:disease
leukemia
|
|
gptkbp:affects
|
adults
children
T lymphocytes
|
|
gptkbp:cellOrigin
|
precursor T cells
|
|
gptkbp:commonIn
|
males
|
|
gptkbp:diagnosedBy
|
bone marrow biopsy
immunophenotyping
flow cytometry
|
|
gptkbp:differentialDiagnosis
|
gptkb:B-cell_ALL
lymphoblastic lymphoma
|
|
gptkbp:firstDescribed
|
1970s
|
|
gptkbp:fullName
|
gptkb:T-cell_acute_lymphoblastic_leukemia
|
|
gptkbp:geneticAbnormality
|
gptkb:NOTCH1_mutation
CDKN2A deletion
TAL1 rearrangement
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
T-cell ALL
|
|
gptkbp:ICD-10_code
|
gptkb:C91.0
|
|
gptkbp:incidence
|
less common than B-cell ALL
|
|
gptkbp:marking
|
gptkb:TdT
gptkb:CD3
gptkb:CD4
gptkb:CD8
gptkb:CD7
gptkb:CD1a
CD2
CD5
|
|
gptkbp:peakAge
|
adolescence
|
|
gptkbp:prognosis
|
variable
better in children
worse in adults
|
|
gptkbp:relapseSite
|
central nervous system
testes
|
|
gptkbp:riskFactor
|
gptkb:Down_syndrome
radiation exposure
genetic mutations
|
|
gptkbp:symptom
|
fever
bleeding
fatigue
hepatosplenomegaly
lymphadenopathy
pallor
|
|
gptkbp:treatment
|
radiation therapy
chemotherapy
stem cell transplantation
|
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gptkbp:bfsParent
|
gptkb:leukemia
|
|
gptkbp:bfsLayer
|
5
|