Statements (58)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:healthcare_organization
|
| gptkbp:affects |
T-lymphocytes
|
| gptkbp:can_lead_to |
bone marrow failure
|
| gptkbp:caused_by |
gptkb:fandom
thrombocytopenia bleeding disorders neutropenia |
| gptkbp:exhibits |
lymphadenopathy
hepatomegaly splenomegaly |
| gptkbp:has_achievements |
infections
|
| gptkbp:has_style |
gptkb:T-cell_acute_lymphoblastic_leukemia
|
| https://www.w3.org/2000/01/rdf-schema#label |
T-cell ALL
|
| gptkbp:is_associated_with |
genetic mutations
elevated white blood cell count CNS involvement hyperleukocytosis poor prognosis in adults |
| gptkbp:is_characterized_by |
high mitotic index
C D3 positivity C D4 or C D8 positivity C D7 positivity abnormal cytogenetics absence of myeloid markers excessive proliferation of T-cells high levels of lactate dehydrogenase (LDH) lymphoblasts |
| gptkbp:is_monitored_by |
blood tests
|
| gptkbp:is_often_used_in |
gptkb:Person
males Asian populations African American populations Hispanic populations |
| gptkbp:is_related_to |
gptkb:Philadelphia_chromosome
gptkb:IL-7_receptor_mutations epigenetic changes Notch signaling pathway increased risk of secondary malignancies cytogenetic abnormalities TCR gene rearrangements micro RNA dysregulation |
| gptkbp:is_studied_in |
biomarker discovery
clinical trials long-term effects of treatment treatment resistance survival outcomes |
| gptkbp:occurs_in |
previous chemotherapy
|
| gptkbp:recognizes |
flow cytometry
|
| gptkbp:scientific_classification |
hematologic malignancy
|
| gptkbp:social_responsibility |
bone marrow biopsy
variable outcomes |
| gptkbp:treatment |
gptkb:vaccine
radiation therapy chemotherapy targeted therapy stem cell transplant |
| gptkbp:bfsParent |
gptkb:healthcare_organization
|
| gptkbp:bfsLayer |
3
|