|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:ARK
gptkb:TYRO7
UFO
|
|
gptkbp:associatedWith
|
gptkb:chronic_myelogenous_leukemia
gptkb:cancer
solid tumors
|
|
gptkbp:discoveredBy
|
Yarden Y et al.
|
|
gptkbp:encodes
|
AXL receptor tyrosine kinase
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000167601
558
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:firstDescribed
|
1991
|
|
gptkbp:function
|
cell proliferation
cell survival
cell migration
immune regulation
|
|
gptkbp:HGNC_ID
|
9052
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
AXL gene
|
|
gptkbp:inhibitedBy
|
gptkb:gilteritinib
gptkb:cabozantinib
R428
bemcentinib
|
|
gptkbp:involvedIn
|
signal transduction
angiogenesis
drug resistance
phagocytosis
immune escape
|
|
gptkbp:ligand
|
gptkb:GAS6
|
|
gptkbp:locatedOnChromosome
|
19q13.2
|
|
gptkbp:mutationAssociatedWith
|
oncogenic potential
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:zebrafish
right
|
|
gptkbp:overexpressedIn
|
gptkb:cancer
leukemia
pancreatic cancer
|
|
gptkbp:pathway
|
gptkb:MAPK_pathway
gptkb:PI3K/AKT_pathway
gptkb:NF-κB_pathway
gptkb:JAK/STAT_pathway
|
|
gptkbp:proteinFamily
|
TAM receptor family
|
|
gptkbp:regulates
|
apoptosis
inflammation
epithelial-mesenchymal transition
|
|
gptkbp:target
|
cancer therapeutics
|
|
gptkbp:UniProtID
|
P30530
|
|
gptkbp:bfsParent
|
gptkb:AXL
|
|
gptkbp:bfsLayer
|
7
|