beta-catenin destruction complex
GPTKB entity
Statements (22)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:component |
gptkb:Axin
gptkb:GSK3β gptkb:APC gptkb:CK1 |
| gptkbp:discoveredBy |
1990s
|
| gptkbp:dysregulationAssociatedWith |
gptkb:cancer
colorectal cancer |
| gptkbp:function |
regulation of Wnt signaling pathway
degradation of beta-catenin |
| https://www.w3.org/2000/01/rdf-schema#label |
beta-catenin destruction complex
|
| gptkbp:inhibitedBy |
gptkb:Wnt_signaling
Wnt signaling in absence of Wnt ligand |
| gptkbp:interactsWith |
beta-TrCP
|
| gptkbp:involves |
proteasomal degradation
|
| gptkbp:location |
gptkb:cytoplasm
|
| gptkbp:modulatedBy |
Wnt ligand binding
|
| gptkbp:phosphorylates |
gptkb:beta-catenin
|
| gptkbp:regulates |
beta-catenin stability
|
| gptkbp:targets_for_ubiquitination |
gptkb:beta-catenin
|
| gptkbp:bfsParent |
gptkb:Frizzled/LRP5/6_receptor_complex
|
| gptkbp:bfsLayer |
7
|