Statements (52)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:binds |
cell membranes
|
| gptkbp:conservedIn |
animals
fungi plants |
| gptkbp:discoveredIn |
1990s
|
| gptkbp:firstDescribed |
Harvey McMahon
Peter De Camilli |
| gptkbp:foundIn |
gptkb:BIN1
proteins Amphiphysin Endophilin Rvs167 Sorting nexin |
| gptkbp:fullName |
Bin/Amphiphysin/Rvs domain
|
| gptkbp:function |
membrane curvature induction
membrane curvature sensing |
| gptkbp:GO_term |
GO:0032581
|
| https://www.w3.org/2000/01/rdf-schema#label |
BAR domain
|
| gptkbp:interactsWith |
actin cytoskeleton
phospholipids |
| gptkbp:InterPro |
IPR004148
|
| gptkbp:involvedIn |
vesicle trafficking
endocytosis cell morphogenesis |
| gptkbp:mechanismOfAction |
dimerization
scaffolding curvature generation membrane binding |
| gptkbp:mutationAssociatedWith |
gptkb:centronuclear_myopathy
neurological disorders |
| gptkbp:namedAfter |
Amphiphysin protein
Bin protein Rvs protein |
| gptkbp:PDB |
1URU
|
| gptkbp:presentIn |
eukaryotes
|
| gptkbp:proteinFamily |
PF03114
|
| gptkbp:relatedTo |
cellular signaling
membrane tubulation |
| gptkbp:reviewedBy |
gptkb:Nature_Reviews_Molecular_Cell_Biology
gptkb:EMBO_Journal Cell |
| gptkbp:SCOP |
1URU
|
| gptkbp:structure |
banana-shaped dimer
|
| gptkbp:subspecies |
F-BAR domain
I-BAR domain N-BAR domain |
| gptkbp:UniProtID |
KW-1002
|
| gptkbp:bfsParent |
gptkb:APPL1
gptkb:amphiphysin gptkb:endophilin |
| gptkbp:bfsLayer |
7
|