|
gptkbp:instanceOf
|
class of medications
|
|
gptkbp:contraindication
|
severe liver disease
severe renal disease
|
|
gptkbp:discoveredIn
|
1960s
|
|
gptkbp:drugInteraction
|
statins
oral anticoagulants
|
|
gptkbp:effect
|
increase HDL cholesterol
lower triglyceride levels
modestly lower LDL cholesterol
|
|
gptkbp:example
|
gptkb:gemfibrozil
gptkb:bezafibrate
gptkb:ciprofibrate
fenofibrate
|
|
gptkbp:excretion
|
kidneys
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
fibrates
|
|
gptkbp:mechanismOfAction
|
activate peroxisome proliferator-activated receptor alpha (PPARĪ±)
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:pregnancyCategory
|
C (varies by country and agent)
|
|
gptkbp:regulates
|
prescription only
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
liver dysfunction
muscular dystrophy
gallstones
|
|
gptkbp:usedFor
|
treatment of hypertriglyceridemia
treatment of hyperlipidemia
|
|
gptkbp:bfsParent
|
gptkb:cerivastatin
gptkb:type_III_hyperlipoproteinemia
gptkb:APOA1
gptkb:High-density_lipoprotein_(HDL)
gptkb:VLDL_cholesterol
|
|
gptkbp:bfsLayer
|
7
|